| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiological Science and Brain Research Institute, University of California, Los Angeles, California 90095-1527
Received 11 March 1996; accepted in final form 14 August 1996.
Talmadge, Robert J., Roland R. Roy, and V. Reggie Edgerton.
Distribution of myosin heavy chain isoforms in non-weight-bearing rat soleus muscle fibers. J. Appl.
Physiol. 81(6): 2540-2546, 1996.
The effects of
14 days of spaceflight (SF) or hindlimb suspension (HS) (Cosmos 2044)
on myosin heavy chain (MHC) isoform content of the rat soleus muscle
and single muscle fibers were determined. On the basis of
electrophoretic analyses, there was a de novo synthesis of type IIx MHC
but no change in either type I or IIa MHC isoform proportions after
either SF or HS compared with controls. The percentage of fibers
containing only type I MHC decreased by 26 and 23%, and the percentage
of fibers with multiple MHCs increased from 6% in controls to 32% in
HS and 34% in SF rats. Type IIx MHC was always found in combination
with another MHC or combination of MHCs; i.e., no fibers contained type
IIx MHC exclusively. These data suggest that the expression of the
normal complement of MHC isoforms in the adult rat soleus muscle is
dependent, in part, on normal weight bearing and that the absence of
weight bearing induces a shift toward type IIx MHC protein expression in the preexisting type I and IIa fibers of the soleus.
contractile proteins; fiber type; gravity; hindlimb suspension; spaceflight
This article has been cited by other articles:
|
|
 |
|
  H. S. Rhee, C. M. Steel, F. J. Derksen, N. E. Robinson, and J. F.Y. Hoh Immunohistochemical Analysis of Laryngeal Muscles in Normal Horses and Horses With Subclinical Recurrent Laryngeal Neuropathy J. Histochem. Cytochem., August 1, 2009; 57(8): 787 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Trappe, D. Costill, P. Gallagher, A. Creer, J. R. Peters, H. Evans, D. A. Riley, and R. H. Fitts Exercise in space: human skeletal muscle after 6 months aboard the International Space Station J Appl Physiol, April 1, 2009; 106(4): 1159 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. D. Wang, F. Kawano, Y. Matsuoka, K. Fukunaga, M. Terada, M. Sudoh, A. Ishihara, and Y. Ohira Mechanical load-dependent regulation of satellite cell and fiber size in rat soleus muscle Am J Physiol Cell Physiol, April 1, 2006; 290(4): C981 - C989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nihei, A. Kobiyama, D. Ikeda, Y. Ono, S. Ohara, N. J. Cole, I. A. Johnston, and S. Watabe Molecular cloning and mRNA expression analysis of carp embryonic, slow and cardiac myosin heavy chain isoforms J. Exp. Biol., January 1, 2006; 209(1): 188 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Cormery, E. Beaumont, K. Csukly, and P. Gardiner Hindlimb unweighting for 2 weeks alters physiological properties of rat hindlimb motoneurones J. Physiol., November 1, 2005; 568(3): 841 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.A.M Korfage, J.H. Koolstra, G.E.J. Langenbach, and T.M.G.J. van Eijden Fiber-type Composition of the Human Jaw Muscles--(Part 2) Role of Hybrid Fibers and Factors Responsible for Inter-individual Variation Journal of Dental Research, September 1, 2005; 84(9): 784 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mounier, V. Montel, F. Picquet, L. Stevens, B. Bastide, and M. Falempin Dual effect of deafferentation on contractile characteristics and sarcoplasmic reticulum properties in rat soleus fibers J Appl Physiol, August 1, 2005; 99(2): 542 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Pellegrino, G. D'Antona, S. Bortolotto, F. Boschi, O. Pastoris, R. Bottinelli, B. Polla, and C. Reggiani Clenbuterol antagonizes glucocorticoid-induced atrophy and fibre type transformation in mice Exp Physiol, January 1, 2004; 89(1): 89 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. J. Caiozzo, M. J. Baker, K. Huang, H. Chou, Y. Z. Wu, and K. M. Baldwin Single-fiber myosin heavy chain polymorphism: how many patterns and what proportions? Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R570 - R580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Picquet, V. Bouet, M. H. Canu, L. Stevens, Y. Mounier, M. Lacour, and M. Falempin Contractile properties and myosin expression in rats born and reared in hypergravity Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1687 - R1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Mozdziak, P. M. Pulvermacher, and E. Schultz Muscle regeneration during hindlimb unloading results in a reduction in muscle size after reloading J Appl Physiol, July 1, 2001; 91(1): 183 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kischel, B. Bastide, L. Stevens, and Y. Mounier Expression and functional behavior of troponin C in soleus muscle fibers of rat after hindlimb unloading J Appl Physiol, March 1, 2001; 90(3): 1095 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. De-Doncker, F. Picquet, and M. Falempin Effects of cutaneous receptor stimulation on muscular atrophy developed in hindlimb unloading condition J Appl Physiol, December 1, 2000; 89(6): 2344 - 2351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bortolotto, M. Cellini, D. G. Stephenson, and G. M. M. Stephenson MHC isoform composition and Ca2+- or Sr2+-activation properties of rat skeletal muscle fibers Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1564 - C1577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Z. Wu, M. J. Baker, R. L. Crumley, and V. J. Caiozzo Single-Fiber Myosin Heavy-Chain Isoform Composition of Rodent Laryngeal Muscle: Modulation by Thyroid Hormone Arch Otolaryngol Head Neck Surg, July 1, 2000; 126(7): 874 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cormery, F. Pons, J.-F. Marini, and P. F. Gardiner Myosin heavy chains in fibers of TTX-paralyzed rat soleus and medial gastrocnemius muscles J Appl Physiol, January 1, 2000; 88(1): 66 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Mozdziak, P. M. Pulvermacher, and E. Schultz Unloading of juvenile muscle results in a reduced muscle size 9 wk after reloading J Appl Physiol, January 1, 2000; 88(1): 158 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Stevens, K. R. Sultan, H. Peuker, B. Gohlsch, Y. Mounier, and D. Pette Time-dependent changes in myosin heavy chain mRNA and protein isoforms in unloaded soleus muscle of rat Am J Physiol Cell Physiol, December 1, 1999; 277(6): C1044 - C1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saitoh, T. Okumoto, H. Nakano, M. Wada, and S. Katsuta Age effect on expression of myosin heavy and light chain isoforms in suspended rat soleus muscle J Appl Physiol, May 1, 1999; 86(5): 1483 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cros, J. Muller, S. Bouju, G. Pietu, C. Jacquet, J. J. Leger, J.-F. Marini, and C. A. Dechesne Upregulation of M-creatine kinase and glyceraldehyde3-phosphate dehydrogenase: two markers of muscle disuse Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1999; 276(2): R308 - R316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Caiozzo, M. J. Baker, and K. M. Baldwin Novel transitions in MHC isoforms: separate and combined effects of thyroid hormone and mechanical unloading J Appl Physiol, December 1, 1998; 85(6): 2237 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Dupont-Versteegden, J. D. Houle, C. M. Gurley, and C. A. Peterson Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise Am J Physiol Cell Physiol, October 1, 1998; 275(4): C1124 - C1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Mozdziak, M. L. Greaser, and E. Schultz Myogenin, MyoD, and myosin expression after pharmacologically and surgically induced hypertrophy J Appl Physiol, April 1, 1998; 84(4): 1359 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Geiger, M. J. Cody, Y. S. Han, L. W. Hunter, W.-Z. Zhan, and G. C. Sieck Effects of hypothyroidism on maximum specific force in rat diaphragm muscle fibers J Appl Physiol, April 1, 2002; 92(4): 1506 - 1514. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
