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J Appl Physiol 81: 2456-2460, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology
Vol. 81, No. 6, pp. 2456-2460, December 1996
CELLULAR ASPECTS OF LUNG FUNCTION

Nitric oxide decreases lung injury after intestinal ischemia

Lance S. Terada, Nancy N. Mahr, and Eugene D. Jacobson

University of Colorado Health Sciences Center, Denver, Colorado 80262

Received 4 June 1996; accepted in final form 26 July 1996.

Terada, Lance S., Nancy N. Mahr, and Eugene D. Jacobson. Nitric oxide decreases lung injury after intestinal ischemia. J. Appl. Physiol. 81(6): 2456-2460, 1996.---After injury to a primary organ, mediators are released into the circulation and may initiate inflammation of remote organs. We hypothesized that the local production of nitric oxide (NO) may act to limit the spread of inflammation to secondarily targeted organs. In anesthetized rats, 30 min of intestinal ischemia followed by 2 h of reperfusion (I/R) did not increase lung albumin leak. However, after treatment with NG-nitro-L-arginine methyl ester (L-NAME), intestinal I/R led to increased lung leak, suggesting a protective effect of endogenous NO. The site of action of NO appeared to be the lung and not the gut because 1) after treatment with L-NAME, local delivery of NO to the lung by inhalation abolished the increase in intestinal I/R-induced lung leak; 2) L-NAME had no effect on epithelial permeability (51Cr-labeled EDTA clearance) of reperfused small bowel; and 3) after treatment with L-NAME, local delivery of NO to the gut by luminal perfusion did not improve epithelial permeability of reperfused intestines. Furthermore, L-NAME increased, and inhaled NO de- creased, the density of lung neutrophils in rats subjected to intestinal I/R, and treatment with the selectin antagonist fucoidan abolished L-NAME-induced lung leak in rats subjected to intestinal I/R. We conclude that endogenous lung NO limits secondary lung injury after intestinal I/R by decreasing pulmonary neutrophil retention.

acute respiratory distress syndrome; neutrophils; xanthine oxidase; multiorgan failure; inflammation

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




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