Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 2373-2378, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagase, T.
Right arrow Articles by Fukuchi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagase, T.
Right arrow Articles by Fukuchi, Y.

Journal of Applied Physiology
Vol. 81, No. 6, pp. 2373-2378, December 1996
GAS EXCHANGE, MECHANICS, AND AIRWAYS

Lung tissue behavior in the mouse during constriction induced by methacholine and endothelin-1

Takahide Nagase, Hirotoshi Matsui, Tomoko Aoki, Yasuyoshi Ouchi, and Yoshinosuke Fukuchi

Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan

Received 7 March 1996; accepted in final form 2 August 1996.

Nagase, Takahide, Hirotoshi Matsui, Tomoko Aoki, Yasuyoshi Ouchi, and Yoshinosuke Fukuchi. Lung tissue behavior in the mouse during constriction induced by methacholine and endothelin-1. J. Appl. Physiol. 81(6): 2373-2378, 1996.---Recently, mice have been extensively used to investigate the pathogenesis of pulmonary disease because appropriate murine models, including transgenic mice, are being increasingly developed. However, little information about the lung mechanics of mice is currently available. We questioned whether lung tissue behavior and the coupling between dissipative and elastic processes, hysteresivity (eta ), in mice would be different from those in the other species. To address this question, we investigated whether tissue resistance (Rti) and eta  in mice would be affected by varying lung volume, constriction induced by methacholine (MCh) and endothelin-1 (ET-1), and high-lung-volume challenge during induced constriction. From measured tracheal flow and tracheal and alveolar pressures in open-chest ICR mice during mechanical ventilation [tidal volume = 8 ml/kg, frequency (f) = 2.5 Hz], we calculated lung resistance (RL), Rti, airway resistance (Raw), lung elastance (EL), and eta  (= 2pi fRti/EL). Under baseline conditions, increasing levels of end-expiratory transpulmonary pressure decreased Raw and increased Rti. The administration of aerosolized MCh and intravenous ET-1 increased RL, Rti, Raw, and EL in a dose-dependent manner. Rti increased from 0.207 ± 0.010 to 0.570 ± 0.058 cmH2O · ml-1 · s after 10-7 mol/kg ET-1 (P < 0.01). After induced constriction, increasing end-expiratory transpulmonary pressure decreased Raw. However, eta  was not affected by changing lung volume, constriction induced by MCh and ET-1, or high-lung-volume challenge during induced constriction. These observations suggest that 1) eta  is stable in mice regardless of various conditions, 2) Rti is an important fraction of RL and increases after induced constriction, and 3) mechanical interdependence may affect airway smooth muscle shortening in this species. In mammalian species, including mice, analysis of eta  may indicate that both Rti and EL essentially respond to a similar degree.

hysteresivity; airway resistance; tissue resistance; interdependence

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
D. S. Faffe and W. A. Zin
Lung Parenchymal Mechanics in Health and Disease
Physiol Rev, July 1, 2009; 89(3): 759 - 775.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Yamamoto, T. Nagase, T. Shindo, S. Teramoto, T. Aoki-Nagase, Y. Yamaguchi, Y. Hanaoka, H. Kurihara, and Y. Ouchi
Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice
J Appl Physiol, June 1, 2007; 102(6): 2361 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.C. Kips, G.P. Anderson, J.J. Fredberg, U. Herz, M.D. Inman, M. Jordana, D.M. Kemeny, J. Lotvall, R.A. Pauwels, C.G. Plopper, et al.
Murine models of asthma
Eur. Respir. J., August 1, 2003; 22(2): 374 - 382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Nagase, N. Uozumi, T. Aoki-Nagase, K. Terawaki, S. Ishii, T. Tomita, H. Yamamoto, K. Hashizume, Y. Ouchi, and T. Shimizu
A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L720 - L726.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. T. Bates and C. G. Irvin
Measuring lung function in mice: the phenotyping uncertainty principle
J Appl Physiol, April 1, 2003; 94(4): 1297 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. D. Flandre, P. L. Leroy, and D. J.-M. Desmecht
Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice
J Appl Physiol, March 1, 2003; 94(3): 1129 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Aoki-Nagase, T. Nagase, Y. Oh-hashi, T. Shindo, Y. Kurihara, Y. Yamaguchi, H. Yamamoto, T. Tomita, E. Ohga, R. Nagai, et al.
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice
Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L963 - L970.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Tomioka, J. H. T. Bates, and C. G. Irvin
Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations
J Appl Physiol, July 1, 2002; 93(1): 263 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. NAGASE, S. ISHII, H. SHINDOU, Y. OUCHI, and T. SHIMIZU
Airway Hyperresponsiveness in Transgenic Mice Overexpressing Platelet Activating Factor Receptor Is Mediated by an Atropine-Sensitive Pathway
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 200 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Faffe, P. R. M. Rocco, E. M. Negri, and W. A. Zin
Comparison of rat and mouse pulmonary tissue mechanical properties and histology
J Appl Physiol, January 1, 2002; 92(1): 230 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. H. Oldmixon, K. Carlsson, C. Kuhn III, J. P. Butler, and F. G. Hoppin Jr.
{alpha}-Actin: disposition, quantities, and estimated effects on lung recoil and compliance
J Appl Physiol, July 1, 2001; 91(1): 459 - 473.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. F. M. Gomes, F. Shardonofsky, D. H. Eidelman, and J. H. T. Bates
Respiratory mechanics and lung development in the rat from early age to adulthood
J Appl Physiol, May 1, 2001; 90(5): 1631 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Faffe, G. H. Silva, P. M. P. Kurtz, E. M. Negri, V. L. Capelozzi, P. R. M. Rocco, and W. A. Zin
Lung tissue mechanics and extracellular matrix composition in a murine model of silicosis
J Appl Physiol, April 1, 2001; 90(4): 1400 - 1406.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. F. M. Gomes, X. Shen, R. Ramchandani, R. S. Tepper, and J. H. T. Bates
Comparative respiratory system mechanics in rodents
J Appl Physiol, September 1, 2000; 89(3): 908 - 916.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Nagase, H. Kurihara, Y. Kurihara, T. Aoki-Nagase, R. Nagai, and Y. Ouchi
Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice
J Appl Physiol, December 1, 1999; 87(6): 2020 - 2024.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. NAGASE, S. ISHII, H. KATAYAMA, Y. FUKUCHI, Y. OUCHI, and T. SHIMIZU
Airway Responsiveness in Transgenic Mice Overexpressing Platelet-activating Factor Receptor . Roles of Thromboxanes and Leukotrienes
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1621 - 1627.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. NAGASE, H. KURIHARA, Y. KURIHARA, T. AOKI, Y. FUKUCHI, Y. YAZAKI, and Y. OUCHI
Airway Hyperresponsiveness to Methacholine in Mutant Mice Deficient in Endothelin-1
Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 560 - 564.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online