Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 2358-2364, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matsumoto, K.
Right arrow Articles by Hara, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsumoto, K.
Right arrow Articles by Hara, N.

Journal of Applied Physiology
Vol. 81, No. 6, pp. 2358-2364, December 1996
GAS EXCHANGE, MECHANICS, AND AIRWAYS

Thromboxane causes airway hyperresponsiveness after cigarette smoke-induced neurogenic inflammation

Koichiro Matsumoto, Hisamichi Aizawa, Hiromasa Inoue, Mutsumi Shigyo, Shohei Takata, and Nobuyuki Hara

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Higashiku, Fukuoka 812, Japan

Received 1 February 1996; accepted in final form 22 July 1996.

Matsumoto, Koichiro, Hisamichi Aizawa, Hiromasa Inoue, Mutsumi Shigyo, Shohei Takata, and Nobuyuki Hara. Thromboxane causes airway hyperresponsiveness after cigarette smoke-induced neurogenic inflammation. J. Appl. Physiol. 81(6): 2358-2364, 1996.---We investigated the role of neurogenic inflammation and the subsequent mechanisms in cigarette smoke-induced airway hyperresponsiveness in guinea pigs. Exposure to cigarette smoke was carried out at tidal volume for 3 min. Airway responsiveness to histamine was determined before and after smoke exposure followed by bronchoalveolar lavage (BAL). Plasma extravasation was evaluated by measuring the extravasation of Evans blue dye in the airway. Cigarette smoke produced significant airway hyperresponsiveness and plasma extravasation, with an influx of neutrophils in BAL fluid. FK-224 (10 mg/kg iv), a tachykinin antagonist at NK1 and NK2 receptors, significantly inhibited these changes. The thromboxane (Tx) B2 concentration was increased in BAL fluid after smoke exposure and was significantly inhibited by FK-224. OKY-046 (10 mg/kg iv), a Tx synthase inhibitor, significantly inhibited airway hyperresponsiveness but had no effect on neutrophil influx or plasma extravasation. The results suggest that neurogenic inflammation and the subsequent generation of Tx in the airway are important in the development of the airway hyperresponsiveness induced by cigarette smoke.

guinea pigs; plasma extravasation; neutrophils

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
D. R. Bergren
Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs
J Appl Physiol, February 1, 2001; 90(2): 695 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. FUKUYAMA, H. INOUE, H. AIZAWA, M. OIKE, M. KITAURA, O. YOSHIE, and N. HARA
Effect of Eotaxin and Platelet-activating Factor on Airway Inflammation and Hyperresponsiveness in Guinea Pigs in Vivo
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1844 - 1849.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. INOUE, H. AIZAWA, H. NAKANO, K. MATSUMOTO, K. KUWANO, J. A. NADEL, and N. HARA
Nitric Oxide Synthase Inhibitors Attenuate Ozone-induced Airway Inflammation in Guinea Pigs . Possible Role of Interleukin-8
Am. J. Respir. Crit. Care Med., January 1, 2000; 161(1): 249 - 256.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
Z.-X. Wu and L.-Y. Lee
Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins
J Appl Physiol, November 1, 1999; 87(5): 1621 - 1628.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online