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J Appl Physiol 81: 2229-2234, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology
Vol. 81, No. 5, pp. 2229-2234, November 1996
ENVIRONMENT

Hypoxia- and normoxia-induced reversibility of autonomic control in Andean guinea pig heart

Fabiola León-Velarde, Jean-Paul Richalet, Juan-Carlos Chavez, Rachid Kacimi, Maria Rivera-Chira, José-Antonio Palacios, and Daniel Clark

Universidad Peruana Cayetano Heredia, Departamento de Ciencias Fisiológicas/ Instituto de Investigaciones de la Altura, Lima 100, Peru; Association pour la Recherche en Physiologie de l'Environnement, 93012 Bobigny; and Institut National de la Santé et de la Recherche Médicale Unité 400, 94010 Créteil, France

Received 13 September 1995; accepted in final form 15 July 1996.

León-Velarde, Fabiola, Jean-Paul Richalet, Juan-Carlos Chavez, Rachid Kacimi, Maria Rivera-Chira, José-Antonio Palacios, and Daniel Clark. Hypoxia- and normoxia-induced reversibility of autonomic control in Andean guinea pig heart. J. Appl. Physiol. 81(5): 2229-2234, 1996.---We herein describe the regulation of cardiac receptors in a typical high-altitude native animal. Heart rate response to isoproterenol (HRIso) (beats · min-1 · mg Iso · kg-1) and atropine, the density of beta -adrenergic (beta AR) and muscarinic (M2) receptors, and the ventricular content of norepinephrine (NE) and dopamine (DA) were studied in guinea pigs (Cavia porcellus). Animals native to Lima, Peru (150 m) were studied at sea level (SL) and after 5 wk at 4,300-m altitude (SL-HA). Animals native to Rancas [Pasco, Peru (4,300 m)] were studied at high altitude (HA) and after 5 wk at SL (HA-SL). HA animals had a lower HRIso, maximum number of beta AR binding sites (Bmax), beta AR dissociation constant (Kd), NE, and DA (P < 0.05) and a higher M2 Bmax (P < 0.001) when compared with the SL group. HA-SL showed an increase of the HRIso, beta AR Kd, and NE (P < 0.05) and a decrease of the M2 Bmax and Kd (P < 0.0001) when compared with the HA group. The present study demonstrates the differential regulation and reversibility of the autonomic control in the guinea pig heart.

high altitude; beta -adrenergic receptors; muscarinic receptors; norepinephrine; isoproterenol

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




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