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Commissariat à l'Énergie Atomique-Service Hospitalier Frédéric Joliot, Groupe de Résonance Magnétique Nucléaire, 91401 Orsay Cedex, France; and Cardiac Unit and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Boston, Massachusetts 02114
Received 11 July 1995; accepted in final form 25 March 1996.
Toussaint, Jean-François, Kenneth K. Kwong, Fidelis
M'Kparu, Robert M. Weisskoff, Paul J. LaRaia, and Howard L. Kantor. Interrelationship of oxidative metabolism and local perfusion demonstrated by NMR in human skeletal muscle. J. Appl.
Physiol. 81(5): 2221-2228, 1996.
Using nuclear
magnetic resonance (NMR), we have examined the relationship of
high-energy phosphate metabolism and perfusion in human soleus and
gastrocnemius muscles. With 31P-NMR spectroscopy, we monitored
phosphocreatine (PCr) decay and recovery in eight normal volunteers and
four heart failure patients performing ischemic plantar flexion. By
using echo-planar imaging, perfusion was independently measured by a
local [inversion-recovery (T1-flow)] and a regional
technique (NMR-plethysmography). After correction for its pH
dependence, PCr recovery time constant is 27.5 ± 8.0 s in
normal volunteers, with mean flow 118 ± 75 (soleus and
gastrocnemius T1-flow) and 30.2 ± 9.7 ml · 100 ml
1 · min1
(NMR-plethysmography-flow). We demonstrate a positive correlation between PCr time constant and local perfusion given by
y = 50 
0.15x
(r2 = 0.68, P = 0.01) for the 8 normal subjects,
and y = 64 0.24x (r2 = 0.83, P = 0.0001) for the 12 subjects
recruited in the study. Regional perfusion techniques also show a
significant but weaker correlation. Using this totally noninvasive
method, we conclude that aerobic ATP resynthesis is related to the
magnitude of perfusion, i.e., O2
availability, and demonstrate that magnetic resonance imaging and
magnetic resonance spectroscopy together can accurately assess muscle
functional status.
nuclear magnetic resonance; magnetic resonance imaging; magnetic resonance spectroscopy;
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