Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 2214-2220, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Lunteren, E.
Right arrow Articles by Moyer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Lunteren, E.
Right arrow Articles by Moyer, M.

Journal of Applied Physiology
Vol. 81, No. 5, pp. 2214-2220, November 1996
EXERCISE AND MUSCLE

Effects of DAP on diaphragm force and fatigue, including fatigue due to neurotransmission failure

Erik Van Lunteren and Michelle Moyer

Department of Medicine, Pulmonary Division, Case Western Reserve University and Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106

Received 26 December 1995; accepted in final form 29 May 1996.

Van Lunteren, Erik, and Michelle Moyer. Effects of DAP on diaphragm force and fatigue, including fatigue due to neurotransmission failure. J. Appl. Physiol. 81(5): 2214-2220, 1996.---Among the aminopyridines, 3,4-diaminopyridine (DAP) is a more effective K+ channel blocker than is 4-aminopyridine (4-AP), and, furthermore, DAP enhances neuromuscular transmission. Because 4-AP improves muscle contractility, we hypothesized that DAP would also increase force and, in addition, ameliorate fatigue and improve the neurotransmission failure component of fatigue. Rat diaphragm strips were studied in vitro (37°C). In field-stimulated muscle, 0.3 mM DAP significantly increased diaphragm twitch force, prolonged contraction time, and shifted the force-frequency relationship to the left without altering peak tetanic force, resulting in increased force at stimulation frequencies <= 50 Hz. During 20-Hz intermittent stimulation, DAP increased diaphragm peak force compared with control during a 150-s fatigue run and, furthermore, significantly improved maintenance of intratrain force. The relative contribution of neurotransmission failure to fatigue was estimated by comparing the force generated by phrenic nerve-stimulated muscles with that generated by curare-treated field-stimulated muscles. DAP significantly increased force in nerve-stimulated muscles and, in addition, reduced the neurotransmission failure contribution to diaphragm fatigue. Thus DAP increases muscle force at low-to-intermediate stimulation frequencies, improves overall force and intratrain fatigue during 20-Hz intermittent stimulation, and reduces neurotransmission failure.

potassium channel; skeletal muscle; contractility; respiratory muscle; 3,4-diaminopyridine

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. K. Dua, N. Dua, and C. L. Murrant
Skeletal muscle contraction-induced vasodilator complement production is dependent on stimulus and contraction frequency
Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H433 - H442.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
E. van Lunteren, J. Pollarine, and M. Moyer
Isotonic contractile impairment due to genetic CLC-1 chloride channel deficiency in myotonic mouse diaphragm muscle
Exp Physiol, July 1, 2007; 92(4): 717 - 729.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. L. Armstrong, A. K. Dua, and C. L. Murrant
Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle
J. Physiol., June 1, 2007; 581(2): 841 - 852.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. van Lunteren, M. Moyer, and H. J. Kaminski
Adverse effects of myasthenia gravis on rat phrenic diaphragm contractile performance
J Appl Physiol, September 1, 2004; 97(3): 895 - 901.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. CLAUSEN
Na+-K+ Pump Regulation and Skeletal Muscle Contractility
Physiol Rev, October 1, 2003; 83(4): 1269 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. van Lunteren and M. Moyer
Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels
J Appl Physiol, August 1, 2003; 95(2): 602 - 610.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Farchi, H. Soreq, and B. Hochner
Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology
J. Physiol., January 1, 2003; 546(1): 165 - 173.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Moyer and E. van Lunteren
Effect of Phasic Activation on Endplate Potential in Rat Diaphragm
J Neurophysiol, December 1, 1999; 82(6): 3030 - 3040.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. van Lunteren and M. Moyer
Peptide toxin blockers of voltage-sensitive K+ channels: inotropic effects on diaphragm
J Appl Physiol, March 1, 1999; 86(3): 1009 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. van LUNTEREN and M. MOYER
Electrophysiologic and Inotropic Effects of K+-Channel Blockade in Aged Diaphragm
Am. J. Respir. Crit. Care Med., September 1, 1998; 158(3): 820 - 826.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Van Lunteren, M. Moyer, and A. Torres
ATP-sensitive K+ channel blocker glibenclamide and diaphragm fatigue during normoxia and hypoxia
J Appl Physiol, August 1, 1998; 85(2): 601 - 608.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online