| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Pulmonary/Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center Burns and Allen Research Institute, Cedars-Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California 90048; and Departments of Anesthesiology and Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905
Received 20 June 1995; accepted in final form 27 June 1996.
Lewis, Michael I., Thomas J. Lorusso, Wen-Zhi Zhan, and Gary
C. Sieck. Interactive effects of denervation and malnutrition on
diaphragm structure and function. J. Appl.
Physiol. 81(5): 2165-2172, 1996.
The purpose of
this study was to examine the interactive effects of unilateral
denervation (DN) and prolonged malnutrition (MN) on the structure and
function of the diaphragm muscle (Dia). Four groups of
rats were studied: control (Con), MN, DN, and DN-MN. MN
began 2 wk after DN and lasted 4 wk. In both the DN and DN-MN groups,
the relative loss in Dia weight exceeded the relative change in body
weight. Compared with the Con group, Dia specific force was reduced by
~40% in both the DN and DN-MN groups but was unaffected in the MN
group. Dia fatigue resistance improved in all experimental groups but
to a greater extent in the DN and DN-MN groups. In both the DN and
DN-MN groups, ~50% of Dia fibers were classified as type IIc,
whereas fiber type proportions did not change in the MN group. In the
DN group, only type IIb/x fibers atrophied, whereas all fiber types
atrophied in the MN and DN-MN groups. We conclude that in the DN-MN
group the reduction in specific force combined with the reduction in total cross-sectional area of the muscle significantly curtails Dia
force-generating capacity.
diaphragm contractility; diaphragm fiber type proportions; diaphragm fiber cross-sectional area
This article has been cited by other articles:
|
|
 |
|
  G. C. Sieck, W.-Z. Zhan, Y.-S. Han, and Y. S. Prakash Effect of denervation on ATP consumption rate of diaphragm muscle fibers J Appl Physiol, September 1, 2007; 103(3): 858 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Dias, C. P. Passaro, V. R. Cagido, M. Einicker-Lamas, J. Lowe, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling J Appl Physiol, November 1, 2004; 97(5): 1888 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Polla, G D'Antona, R Bottinelli, and C Reggiani Respiratory muscle fibres: specialisation and plasticity Thorax, September 1, 2004; 59(9): 808 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Vassilakopoulos and B. J. Petrof Ventilator-induced Diaphragmatic Dysfunction Am. J. Respir. Crit. Care Med., February 1, 2004; 169(3): 336 - 341. [Full Text] [PDF]
|
|
|
|
|
|
P. C. Geiger, J. P. Bailey, W.-Z. Zhan, C. B. Mantilla, and G. C. Sieck Denervation-induced changes in myosin heavy chain expression in the rat diaphragm muscle J Appl Physiol, August 1, 2003; 95(2): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Z. Racz, G. Gayan-Ramirez, D. Testelmans, P. Cadot, K. De Paepe, E. Zador, F. Wuytack, and M. Decramer Early Changes in Rat Diaphragm Biology with Mechanical Ventilation Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 297 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Laghi and M. J. Tobin Disorders of the Respiratory Muscles Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Laghi, S. E. Cattapan, A. Jubran, S. Parthasarathy, P. Warshawsky, Y.-S. A. Choi, and M. J. Tobin Is Weaning Failure Caused by Low-Frequency Fatigue of the Diaphragm? Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 120 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. H. Sassoon Ventilator-associated Diaphragmatic Dysfunction Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1017 - 1018. [Full Text] [PDF]
|
|
|
|
|
|
L. Yang, J. Luo, J. Bourdon, M.-C. Lin, S. B. Gottfried, and B. J. Petrof Controlled Mechanical Ventilation Leads to Remodeling of the Rat Diaphragm Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1135 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Sieck and W.-Z. Zhan Denervation alters myosin heavy chain expression and contractility of developing rat diaphragm muscle J Appl Physiol, September 1, 2000; 89(3): 1106 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Coirault, D. Chemla, and Y. Lecarpentier Relaxation of diaphragm muscle J Appl Physiol, October 1, 1999; 87(4): 1243 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fruhbeck, A. C. Villaro, I. Monreal, and S. Santidrian Hormone-related, muscle-specific changes in protein metabolism and fiber type profile after faba bean intake J Appl Physiol, March 1, 1999; 86(3): 852 - 859. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
