| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208-3107
Received 15 December 1995; accepted in final form 10 July 1996.
Liu, S. Q. Alterations in structure of elastic laminae
of rat pulmonary arteries in hypoxic hypertension. J. Appl. Physiol. 81(5): 2147-2155, 1996.
The effect
of hypoxic hypertension on the remodeling process of the elastic
laminae of the rat hilar pulmonary arteries (PAs) was studied by
electron microscopy. Rats were exposed to hypoxia (10%
O2) for periods of 0.5, 2, 6, 12, 48, 96, 144, and 240 h. Changes in the structure of the PA elastic laminae were examined and analyzed with respect to changes in the PA
wall tensile stress. The PA blood pressure increased rapidly within the
first several hours of hypoxia and reached a stable level within 2 days, whereas the PA wall tensile stress increased initially due to
elevated blood pressure and then decreased after 48 h due to vessel
wall thickening and returned to the control level after 4 days. In
association with these changes, the elastic laminae, which appeared
homogeneous in normal control rats, changed into structures composed of
randomly oriented filaments and edematous contents with an increase in
the volume during the early period of hypoxia and regained their
homogeneous appearance and normal volume after 4 days. The changes in
the elastic laminae were correlated with changes in the tensile stress.
These changes were associated with a transient decrease in the
stiffness of the PAs. In hypoxic rats given nifedipine, no change was
found in the blood pressure, the tensile stress, or the structure of
the elastic laminae of the PAs despite continuous exposure to hypoxia.
These results suggested that altered tensile stress in the PA wall
played a critical role in the initiation and regulation of structural
changes in the elastic laminae and that these changes might contribute to alterations in the mechanical properties of the PA in hypoxic hypertension.
elastic laminae; mechanical stress; hypoxic hypertension
This article has been cited by other articles:
|
|
 |
|
  T. Haraguchi, K. Okada, Y. Tabata, Y. Maniwa, Y. Hayashi, and Y. Okita Controlled Release of Basic Fibroblast Growth Factor From Gelatin Hydrogel Sheet Improves Structural and Physiological Properties of Vein Graft in Rat Arterioscler Thromb Vasc Biol, March 1, 2007; 27(3): 548 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Kobs, N. E. Muvarak, J. C. Eickhoff, and N. C. Chesler Linked mechanical and biological aspects of remodeling in mouse pulmonary arteries with hypoxia-induced hypertension Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1209 - H1217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Sauzeau, M. Rolli-Derkinderen, S. Lehoux, G. Loirand, and P. Pacaud Sildenafil Prevents Change in RhoA Expression Induced by Chronic Hypoxia in Rat Pulmonary Artery Circ. Res., October 3, 2003; 93(7): 630 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Krenz and C. A. Dawson Flow and pressure distributions in vascular networks consisting of distensible vessels Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2192 - H2203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Goldman, L. Zhong, and S. Q. Liu Degradation of alpha -actin filaments in venous smooth muscle cells in response to mechanical stretch Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1839 - H1847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bonnet, E. Dubuis, C. Vandier, S. Martin, R. Marthan, and J.-P. Savineau Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing Cardiovasc Res, March 1, 2002; 53(4): 1019 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bonnet, A. Belus, J.-M. Hyvelin, E. Roux, R. Marthan, and J.-P. Savineau Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L193 - L201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, Z. Shen, N. E. Huang, and Y. C. Fung Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia PNAS, March 2, 1999; 96(5): 1834 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, Z. Shen, N. E. Huang, and Y. C. Fung Use of intrinsic modes in biology: Examples of indicial response of pulmonary blood pressure to ± step hypoxia PNAS, October 27, 1998; 95(22): 12766 - 12771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Q. Liu Regression of hypoxic hypertension-induced changes in the elastic laminae of rat pulmonary arteries J Appl Physiol, May 1, 1997; 82(5): 1677 - 1684. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
