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J Appl Physiol 81: 2013-2019, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology
Vol. 81, No. 5, pp. 2013-2019, November 1996
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Developmental changes in endothelium-dependent relaxation of pulmonary arteries: role of EDNO and prostanoids

Denise C. O'Donnell, Mary L. Tod, and John B. Gordon

Departments of Pediatrics, Medicine, and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201

Received 11 May 1995; accepted in final form 14 June 1996.

O'Donnell, Denise C., Mary L. Tod, and John B. Gordon. Developmental changes in endothelium-dependent relaxation of pulmonary arteries: role of EDNO and prostanoids. J. Appl. Physiol. 81(5): 2013-2019, 1996.---We hypothesized that maturational changes in both prostaglandin and endothelium-derived nitric oxide (EDNO) activity contribute to developmental changes in endothelium-dependent relaxation of newborn pulmonary arteries. Responses to endothelium-dependent vasodilators acetylcholine, bradykinin, and calcium ionophore A-23187 were determined in phenylephrine-constricted third- and fourth-generation (1- to 2-mm-diameter) pulmonary artery rings from 2-day (2d)- and 1-mo (1m)-old lambs under control conditions (Con), after inhibition of EDNO synthesis with Nomega -nitro-L-arginine (L-NNA), after inhibition of prostanoid synthesis with meclofenamate (Mec), or both modulators with both inhibitors. Endothelium-independent responses to sodium nitroprusside (SNP) were also measured in Con rings. Endothelium-dependent relaxation was greater in 2d than 1m Con rings, particularly at high concentrations when an increase in tension occurred in 1m rings. L-NNA attenuated endothelium-dependent relaxation more in 2d rings, and SNP caused greater relaxation in 2d rings. However, Mec abolished all age-related differences by attenuating relaxation in 2d rings and constriction in 1m rings. These data suggest that developmental changes in endothelium-dependent responses of ovine pulmonary artery rings reflect both a decrease in EDNO activity and maturational differences in the relative influence of dilator and constrictor prostanoids.

endothelium-derived relaxing factor; thromboxane; acetylcholine; bradykinin; calcium ionophore; sodium nitroprusside; endothelium-derived nitric oxide

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




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