Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 1924-1928, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Asp, S.
Right arrow Articles by Richter, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Asp, S.
Right arrow Articles by Richter, E. A.

Journal of Applied Physiology
Vol. 81, No. 5, pp. 1924-1928, November 1996
EXERCISE AND MUSCLE

Decreased insulin action on muscle glucose transport after eccentric contractions in rats

Sven Asp and Erik A. Richter

Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark

Received 6 February 1996; accepted in final form 3 July 1996.

Asp, Sven, and Erik A. Richter. Decreased insulin action on muscle glucose transport after eccentric contractions in rats. J. Appl. Physiol. 81(5): 1924-1928, 1996.---We have recently shown that eccentric contractions (Ecc) of rat calf muscles cause muscle damage and decreased glycogen and glucose transporter GLUT-4 protein content in the white (WG) and red gastrocnemius (RG) but not in the soleus (S) (S. Asp, S. Kristiansen, and E. A. Richter. J. Appl. Physiol. 79: 1338-1345, 1995). To study whether these changes affect insulin action, hindlimbs were perfused at three different insulin concentrations (0, 200, and 20,000 µU/ml) 2 days after one-legged eccentric contractions of the calf muscles. Compared with control, basal glucose transport was slightly higher (P < 0.05) in Ecc-WG and -RG, whereas it was lower (P < 0.05) at both submaximal and maximal insulin concentrations in the Ecc-WG and at maximal concentrations in the Ecc-RG. In the Ecc-S, the glucose transport was unchanged in hindquarters perfused in the absence or presence of a submaximal stimulating concentration of insulin, whereas it was slightly (P < 0.05) higher during maximal insulin stimulation compared with control S. At the end of perfusion the glycogen concentrations were lower in both Ecc-gastrocnemius muscles compared with control muscles at all insulin concentrations. Fractional velocity of glycogen synthase increased similarly with increasing insulin concentrations in Ecc- and control WG and RG. We conclude that insulin action on glucose transport but not glycogen synthase activity is impaired in perfused muscle exposed to prior eccentric contractions.

skeletal muscle; insulin resistance

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Am. Coll. Nutr.Home page
W. J. Evans
Protein Nutrition, Exercise and Aging
J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 601S - 609S.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Hernandez, M. J. Fedele, and P. A. Farrell
Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats
J Appl Physiol, March 1, 2000; 88(3): 1142 - 1149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. F. del Aguila, K. P. Claffey, and J. P. Kirwan
TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells
Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E849 - E855.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Asp, A. Watkinson, N. D. Oakes, and E. W. Kraegen
Prior eccentric contractions impair maximal insulin action on muscle glucose uptake in the conscious rat
J Appl Physiol, April 1, 1997; 82(4): 1327 - 1332.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online