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Departments of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21224
Received 23 April 1996; accepted in final form 26 June 1996.
Wagner, Elizabeth M., and W. Michael Foster. Importance
of airway blood flow on particle clearance from the lung.
J. Appl. Physiol. 81(5):
1878-1883, 1996.
The role of the airway circulation in
supporting mucociliary function has been essentially unstudied. We
evaluated the airway clearance of inert, insoluble particles in
anesthetized ventilated sheep (n = 8),
in which bronchial perfusion was controlled, to determine whether
airway mucosal blood flow is essential for maintaining surface
transport of particles through airways. The bronchial branch of the
bronchoesophageal artery was cannulated and perfused with autologous
blood at control flow (0.6 ml · min
1 · kg1)
or perfusion was stopped. With the sheep in a supine position and after
a steady-state 133Xe ventilation
scan for designation of lung zones of interest, an inert
99mTc-labeled sulfur colloid
aerosol (2.1-µm diameter) was deposited in the lung. The clearance
kinetics of the radiolabeled particles were determined from the
activity-time data obtained for right and left lung zones. At 60 min
postdeposition of aerosol, average airway particle retention for
control bronchial blood flow conditions was 57 ± 7 (SE)% for the
right and 53 ± 8% for the left lung zones. Clearance of particles
was significantly impaired when bronchial blood flow was stopped, e.g.,
right and left lung zones averaged 77 ± 6 and 76 ± 7% at 60 min, respectively (P < 0.05). These
data demonstrate a significant influence of the bronchial circulation on mucociliary transport of insoluble particles. Potential mechanisms that may account for these results include the importance of the bronchial circulation for nutrient flow, maintenance of airway wall
temperature and humidity, and release of mediators and sequelae associated with tissue ischemia.
sheep; bronchial artery; mucociliary clearance; insoluble particle transport
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