Journal of Applied Physiology AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 1778-1784, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sinoway, L.
Right arrow Articles by Leuenberger, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sinoway, L.
Right arrow Articles by Leuenberger, U.

Journal of Applied Physiology
Vol. 81, No. 4, pp. 1778-1784, October 1996
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise

Lawrence Sinoway, Jeffrey Shenberger, Gretchen Leaman, Robert Zelis, Kristen Gray, Robert Baily, and Urs Leuenberger

Division of Cardiology, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033; and Lebanon Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042

Received 4 December 1995; accepted in final form 22 May 1996.

Sinoway, Lawrence, Jeffrey Shenberger, Gretchen Leaman, Robert Zelis, Kristen Gray, Robert Baily, and Urs Leuenberger. Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. J. Appl. Physiol. 81(4): 1778-1784, 1996.---We previously demonstrated that nonfatiguing rhythmic forearm exercise at 25% maximal voluntary contraction (12 2-s contractions/min) evokes sympathoexcitation without significant engagement of metabolite-sensitive muscle afferents (B. A. Batman, J. C. Hardy, U. A. Leuenberger, M. B. Smith, Q. X. Yang, and L. I. Sinoway. J. Appl. Physiol. 76: 1077-1081, 1994). This is in contrast to the sympathetic nervous system responses observed during fatiguing static forearm exercise where metabolite-sensitive afferents are the key determinants of sympathetic activation. In this report we examined whether forearm exercise training would attenuate sympathetic nervous system responses to rhythmic forearm exercise. We measured heart rate, mean arterial blood pressure (MAP), muscle sympathetic nerve activity (microneurography), plasma norepinephrine (NE), and NE spillover and clearance (tritiated NE kinetics) during nonfatiguing rhythmic forearm exercise before and after a 4-wk unilateral forearm training paradigm. Training had no effect on forearm mass, maximal voluntary contraction, or heart rate but did attenuate the increase in MAP (increase in MAP: from 15.2 ± 1.8 before training to 11.4 ± 1.4 mmHg after training; P < 0.017), muscle sympathetic nerve activity (increase in bursts: from 10.8 ± 1.4 before training to 6.2 ± 1.1 bursts/min after training; P < 0.030), and the NE spillover (increase in arterial spillover: from 1.3 ± 0.2 before training to 0.6 ± 0.2 nmol · min-1 · m-2 after training, P < 0.014; increase in venous spillover: from 2.0 ± 0.6 before training to 1.0 ± 0.5 nmol · min-1 · m-2 after training, P < 0.037) seen in response to exercise performed by the trained forearm. Thus forearm training reduces sympathetic responses during a nonfatiguing rhythmic handgrip paradigm that does not engage muscle metaboreceptors. We speculate that this effect is due to a conditioning-induced reduction in mechanically sensitive muscle afferent discharge.

exercise conditioning; autonomic nervous system; muscle sympathetic nerve activity and exercise

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Momen, J. Cui, P. McQuillan, and L. I. Sinoway
Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2184 - H2190.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. D. Witt, J. A. Guenette, J. L. Rupert, D. C. McKenzie, and A. W. Sheel
Inspiratory muscle training attenuates the human respiratory muscle metaboreflex
J. Physiol., November 1, 2007; 584(3): 1019 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. A. Alomari, A. Solomito, R. Reyes, S. M. Khalil, R. H. Wood, and M. A. Welsch
Measurements of vascular function using strain-gauge plethysmography: technical considerations, standardization, and physiological findings
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H99 - H107.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. S. Fulco, P. B. Rock, S. R. Muza, E. Lammi, B. Braun, A. Cymerman, L. G. Moore, and S. F. Lewis
Gender alters impact of hypobaric hypoxia on adductor pollicis muscle performance
J Appl Physiol, July 1, 2001; 91(1): 100 - 108.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. R. Middlekauff, E. U. Nitzsche, C. K. Hoh, M. A. Hamilton, G. C. Fonarow, A. Hage, and J. D. Moriguchi
Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure
J Appl Physiol, May 1, 2001; 90(5): 1714 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. A. MacLean, L. M. Vickery, and L. I. Sinoway
Elevated interstitial adenosine concentrations do not activate the muscle reflex
Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H546 - H553.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J.-L. Liu, S. Irvine, I. A. Reid, K. P. Patel, and I. H. Zucker
Chronic Exercise Reduces Sympathetic Nerve Activity in Rabbits With Pacing-Induced Heart Failure : A Role for Angiotensin II
Circulation, October 10, 2000; 102(15): 1854 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. A. Ray and D. I. Carrasco
Isometric handgrip training reduces arterial pressure at rest without changes in sympathetic nerve activity
Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H245 - H249.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Ray
Sympathetic adaptations to one-legged training
J Appl Physiol, May 1, 1999; 86(5): 1583 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Mostoufi-Moab, E. J. Widmaier, J. A. Cornett, K. Gray, and L. I. Sinoway
Forearm training reduces the exercise pressor reflex during ischemic rhythmic handgrip
J Appl Physiol, January 1, 1998; 84(1): 277 - 283.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online