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Departments of Internal Medicine and Pharmacology and Pediatrics, University of California, Davis, California 95616
Received 29 March 1996; accepted in final form 10 June 1996.
Bonham, A. C., K. S. Kott, and J. P. Joad. Sidestream
smoke exposure enhances rapidly adapting receptor responses to substance P in young guinea pigs. J. Appl.
Physiol. 81(4): 1715-1722, 1996.
We determined
the effect of sidestream tobacco smoke (SS) exposure on responses of
lung rapidly adapting receptors (RARs), peak tracheal pressure (Ptr),
and arterial blood pressure (ABP) to substance P in young guinea pigs.
Guinea pigs were exposed to SS or filtered air from
day 8 to days
41-45 of life. They were then anesthetized and
given three doses of intravenous substance P (1.56-4.94 nmol/kg).
SS exposure augmented substance P-evoked increases in RAR activity
(P = 0.029 by analysis of variance) but not substance P-evoked increases in peak Ptr or decreases in ABP.
Neurokinin 1-receptor blockade (CP-96345, 400 nmol/kg) attenuated
substance P-evoked increases in RAR activity
(P = 0.001) and ABP
(P = 0.009) but not in peak Ptr
(P = 0.06). Thus chronic exposure to
SS in young guinea pigs exaggerates RAR responsiveness to substance P. The findings may help explain the increased incidence of airway
hyperresponsiveness and cough in children chronically exposed to
environmental tobacco smoke.
environmental tobacco smoke; airways; vagus; tachykinins
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