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Division of Respiratory and Critical Care Physiology and Medicine, Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90509
Received 23 January 1996; accepted in final form 21 May 1996.
Barstow, Thomas J., Andrew M. Jones, Paul H. Nguyen, and
Richard Casaburi. Influence of muscle fiber type and pedal frequency on oxygen uptake kinetics of heavy exercise.
J. Appl. Physiol. 81(4):
1642-1650, 1996.
We tested the hypothesis that the amplitude of
the additional slow component of
O2 uptake
(
O2) during heavy exercise
is correlated with the percentage of type II (fast-twitch) fibers in
the contracting muscles. Ten subjects performed transitions to a work
rate calculated to require a
O2 equal to 50% between
the estimated lactate (Lac) threshold and maximal
O2 (50%
).
Nine subjects consented to a muscle biopsy of the vastus lateralis. To
enhance the influence of differences in fiber type among subjects,
transitions were made while subjects were pedaling at 45, 60, 75, and
90 rpm in different trials. Baseline O2 was designed to be
similar at the different pedal rates by adjusting baseline work rate
while the absolute increase in work rate above the baseline was the
same. The O2 response after the onset of exercise was described by a three-exponential model. The
relative magnitude of the slow component at the end of 8-min exercise
was significantly negatively correlated with %type I fibers at every
pedal rate (r = 0.64 to 0.83, P < 0.05-0.01). Furthermore,
the gain of the fast component for
O2 (as
ml · min
1 · W1)
was positively correlated with the %type I fibers across pedal rates
(r = 0.69-0.83). Increase in
pedal rate was associated with decreased relative stress of the
exercise but did not affect the relationships between
%fiber type and O2
parameters. The relative contribution of the slow component was also
significantly negatively correlated with maximal
O2
(r = 
0.65), whereas the gain
for the fast component was positively associated
(r = 0.68-0.71 across rpm). The
amplitude of the slow component was significantly correlated with net
end-exercise Lac at all four pedal rates
(r = 0.64-0.84), but Lac was not
correlated with %type I (P > 0.05).
We conclude that fiber type distribution significantly affects both the
fast and slow components of
O2 during heavy exercise
and that fiber type and fitness may have both codependent and
independent influences on the metabolic and gas-exchange responses to
heavy exercise.
energetics; muscle fiber type; pedal frequency; slow component of oxygen uptake
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