Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 1627-1632, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Honda, Y.
Right arrow Articles by Kuriyama, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Honda, Y.
Right arrow Articles by Kuriyama, T.

Journal of Applied Physiology
Vol. 81, No. 4, pp. 1627-1632, October 1996
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans

Y. Honda, H. Tani, A. Masuda, T. Kobayashi, T. Nishino, H. Kimura, S. Masuyama, and T. Kuriyama

Departments of Physiology, Anesthesiology, and Chest Medicine, School of Medicine, Chiba University, and Department of Physical Therapy, International University of Health and Welfare, Ohdawara 324, Japan

Received 5 December 1995; accepted in final form 13 May 1996.

Honda, Y., H. Tani, A. Masuda, T. Kobayashi, T. Nishino, H. Kimura, S. Masuyama, and T. Kuriyama. Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans. J. Appl. Physiol. 81(4): 1627-1632, 1996.---Sixteen healthy volunteers breathed 100% O2 or room air for 10 min in random order, then their ventilatory response to sustained normocapnic hypoxia (80% arterial O2 saturation, as measured with a pulse oximeter) was studied for 20 min. In addition, to detect agents possibly responsible for the respiratory changes, blood plasma of 10 of the 16 subjects was chemically analyzed. 1) Preliminary O2 breathing uniformly and substantially augmented hypoxic ventilatory responses. 2) However, the profile of ventilatory response in terms of relative magnitude, i.e., biphasic hypoxic ventilatory depression, remained nearly unchanged. 3) Augmented ventilatory increment by prior O2 breathing was significantly correlated with increment in the plasma glutamine level. We conclude that preliminary O2 administration enhances hypoxic ventilatory response without affecting the biphasic response pattern and speculate that the excitatory amino acid neurotransmitter glutamate, possibly derived from augmented glutamine, may, at least in part, play a role in this ventilatory enhancement.

normocapnia; mild hypoxia; glutamine-glutamate system

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
F. Leon-Velarde, A. Gamboa, M. Rivera-Ch, J.-A. Palacios, and P. A. Robbins
Plasticity in Respiratory Motor Control: Selected Contribution: Peripheral chemoreflex function in high-altitude natives and patients with chronic mountain sickness
J Appl Physiol, March 1, 2003; 94(3): 1269 - 1278.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Bavis and G. S. Mitchell
Plasticity in Respiratory Motor Control: Selected Contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
J Appl Physiol, January 1, 2003; 94(1): 399 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X. Ren, M. Fatemian, and P. A. Robbins
Changes in respiratory control in humans induced by 8 h of hyperoxia
J Appl Physiol, August 1, 2000; 89(2): 655 - 662.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Gozal
Potentiation of hypoxic ventilatory response by hyperoxia in the conscious rat: putative role of nitric oxide
J Appl Physiol, July 1, 1998; 85(1): 129 - 132.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Gelfand, C. J. Lambertsen, J. M. Clark, and E. Hopkin
Hypoxic ventilatory sensitivity in men is not reduced by prolonged hyperoxia (Predictive Studies V and VI)
J Appl Physiol, January 1, 1998; 84(1): 292 - 302.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online