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Departments of Veterinary Biosciences and Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801
Received 21 February 1996; accepted in final form 23 May 1996.
Manohar, Murli, and Thomas E. Goetz. Pulmonary vascular
pressures of exercising Thoroughbred horses with and without endoscopic
evidence of EIPH. J. Appl. Physiol.
81(4): 1589-1593, 1996.
Exercise-induced pulmonary hemorrhage
(EIPH) is a common occurrence in racehorses. The objective of this
study was to compare pulmonary vascular pressures of healthy
Thoroughbred horses with and without postexertion endoscopically
detectable fresh blood in the trachea. The nasopharynx, larynx, and
trachea (down to the carina) of horses were examined weekly with an
endoscope 55-60 min postexertion, and the diagnosis of EIPH was
confirmed by the presence of fresh blood in the trachea. Measurements
of heart rate and right atrial, pulmonary arterial, and pulmonary
arterial wedge pressures were made during quiet rest and during
treadmill exercise performed at 14.5 m/s on a 5% uphill
grade. This workload elicited maximal heart rate of the
horses. Mean pulmonary capillary pressure was estimated to be halfway
between the mean pulmonary arterial pressure and the mean pulmonary
arterial wedge pressure. These data from 7 healthy sound
exercise-trained horses that were positive on 12 consecutive occasions
(at 1-wk intervals) for the postexercise presence of fresh blood in the
trachea were compared with those in 8 healthy horses that were
consistently negative for the evidence of fresh blood in the trachea on
postexercise endoscopic examination over 12-16 wk. The heart rate
and the right heart and/or pulmonary vascular pressures in the two
groups of horses were similar at rest. Exercise was
attended by a large significant (P < 0.05) increase in these pressures and heart rate in both groups.
However, statistically significant differences between endoscopically
EIPH-positive and endoscopically EIPH-negative horses for heart rate
and right atrial and pulmonary vascular pressures were not found during
exercise. Thus these data revealed that the magnitude of
exercise-induced right atrial as well as pulmonary arterial, capillary,
and venous hypertension in endoscopically EIPH-positive horses that are
otherwise healthy is quite similar to that in endoscopically
EIPH-negative horses during comparable exertion.
exercise-induced pulmonary hemorrhage; pulmonary circulation; pulmonary hemodynamics
This article has been cited by other articles:
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  M. Manohar and T. E. Goetz Intrapulmonary arteriovenous shunts of >15 {micro}m in diameter probably do not contribute to arterial hypoxemia in maximally exercising Thoroughbred horses J Appl Physiol, July 1, 2005; 99(1): 224 - 229. [Abstract] [Full Text] [PDF]
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M. Manohar, T. E. Goetz, and A. S. Hassan NaHCO3 does not affect arterial O2 tension but attenuates desaturation of hemoglobin in maximally exercising Thoroughbreds J Appl Physiol, April 1, 2004; 96(4): 1349 - 1356. [Abstract] [Full Text] [PDF]
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M. Manohar, T. E. Goetz, and A. S. Hassan Preexercise hypervolemia does not affect arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise J Appl Physiol, June 1, 2003; 94(6): 2135 - 2144. [Abstract] [Full Text] [PDF]
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M. Manohar, T. E. Goetz, A. S. Hassan, T. Depuy, and S. Humphrey Anti-inflammatory agent, dexamethasone, does not affect exercise-induced arterial hypoxemia in Thoroughbreds J Appl Physiol, July 1, 2002; 93(1): 99 - 106. [Abstract] [Full Text] [PDF]
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M. Manohar, T. E. Goetz, and A. S. Hassan Nitric oxide synthase inhibition does not affect the exercise-induced arterial hypoxemia in Thoroughbred horses J Appl Physiol, September 1, 2001; 91(3): 1105 - 1112. [Abstract] [Full Text] [PDF]
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M. Manohar, T. E. Goetz, and A. S. Hassan Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses J Appl Physiol, June 1, 2001; 90(6): 2371 - 2377. [Abstract] [Full Text] [PDF]
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T. E. Goetz, M. Manohar, A. S. Hassan, and G. J. Baker Nasal strips do not affect pulmonary gas exchange, anaerobic metabolism, or EIPH in exercising Thoroughbreds J Appl Physiol, June 1, 2001; 90(6): 2378 - 2385. [Abstract] [Full Text] [PDF]
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M. Manohar and T. E. Goetz L-NAME does not affect exercise-induced pulmonary hypertension in Thoroughbred horses J Appl Physiol, June 1, 1998; 84(6): 1902 - 1908. [Abstract] [Full Text] [PDF]
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M. Manohar, T. E. Goetz, S. Humphrey, and T. Depuy H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds J Appl Physiol, April 1, 2002; 92(4): 1515 - 1523. [Abstract] [Full Text] [PDF]
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