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J Appl Physiol 81: 1555-1561, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology
Vol. 81, No. 4, pp. 1555-1561, October 1996
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Development of ventilatory responsiveness to progressive hypoxia and hypercapnia in low-birth-weight lambs

T. J. Moss, M. G. Davey, G. J. McCrabb, and R. Harding

Fetal and Neonatal Research Unit, Department of Physiology, Monash University, Clayton, Victoria 3168, Australia

Received 11 December 1995; accepted in final form 20 May 1996.

Moss, T. J., M. G. Davey, G. J. McCrabb, and R. Harding. Development of ventilatory responsiveness to progressive hypoxia and hypercapnia in low-birth-weight lambs. J. Appl. Physiol. 81(4): 1555-1561, 1996.---Our aim was to determine the effects of low birth weight on ventilatory responses to progressive hypoxia and hypercapnia during early postnatal life. Seven low-birth-weight (2.7 ± 0.3 kg) and five normal-birth-weight (4.8 ± 0.2 kg) lambs, all born at term, underwent weekly rebreathing tests during wakefulness while arterial PO2, PCO2, and pH were measured. Hypoxic ventilatory responsiveness (HOVR; percent increase in ventilation when arterial PO2 fell to 60% of resting values) increased in normal lambs from 86.6 ± 7.1% at week 1 to 227.4 ± 24.9% at week 6. In low-birth-weight lambs, HOVR was not significantly different at week 1 (60.1 ± 18.7%) from that of normal lambs but did not increase with postnatal age (56.6 ± 19.3% at week 6). HOVR of all lambs at 6 wk was significantly correlated with birth weight (r2 = 0.8). Hypercapnic ventilatory responsiveness (gradient of ventilation vs. arterial PCO2) did not change with age and was not significantly different between groups [84.7 ± 7.5 (low-birth-weight lambs) vs. 89.4 ± 6.6 ml · min-1 · kg-1 · mmHg-1 (normal lambs)]. We conclude that intrauterine conditions that impair fetal growth lead to the failure of HOVR to increase with age.

newborn; growth restriction; small for gestational age; rebreathing

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




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