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Department of Kinesiology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
Received 16 January 1996; accepted in final form 4 June 1996.
Shoemaker, J. K., H. L. Naylor, Z. I. Pozeg, and R. L. Hughson. Failure of prostaglandins to modulate the time course of
blood flow during dynamic forearm exercise in humans.
J. Appl. Physiol. 81(4):
1516-1521, 1996.
The time course and magnitude of increases in
brachial artery mean blood velocity (MBV; pulsed Doppler), diameter
(D; echo Doppler), mean perfusion
pressure (MPP; Finapres), shear rate (
= 8 · MBV/D), and
forearm blood flow (FBF = MBV · 
r2)
were assessed to investigate the effect that prostaglandins (PGs) have
on the hyperemic response on going from rest to rhythmic exercise in
humans. While supine, eight healthy men performed 5 min of dynamic
handgrip exercise by alternately raising and lowering a 4.4-kg weight
(~10% maximal voluntary contraction) with a work-to-rest cycle of
1:1 (s/s). When the exercise was performed with the arm positioned
below the heart, the rate of increase in MBV and was
faster compared with the same exercise performed above the heart.
Ibuprofen (Ibu; 1,200 mg/day, to reduce PG-induced vasodilation) and
placebo were administered orally for 2 days before two separate testing
sessions in a double-blind manner. Resting heart rate was reduced in
Ibu (52 ± 3 beats/min) compared with placebo (57 ± 3 beats/min)
(P < 0.05) without change to MPP.
With placebo, D increased in both arm
positions from ~4.3 mm at rest to ~4.5 mm at 5 min of exercise
(P < 0.05). This response was not
altered with Ibu (P > 0.05). Ibu
did not alter the time course of MBV or forearm blood flow
(P > 0.05) in either arm position. The was significantly greater in Ibu vs. placebo at 30 and 40 s of above the heart exercise and for all time points after 25 s
of below the heart exercise (P < 0.05). Because PG inhibition altered the time course of
at the brachial artery, but not FBF, it was concluded
that PGs are not essential in regulating the blood flow responses to
dynamic exercise in humans.
arterial diameter; pulsed Doppler ultrasound; echo Doppler ultrasound
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