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J Appl Physiol 81: 1488-1494, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology
Vol. 81, No. 4, pp. 1488-1494, October 1996
EXERCISE AND MUSCLE

Exercise training improves lusitropy by isoproterenol in papillary muscles from aged rats

George E. Taffet, Lloyd A. Michael, and Charlotte A. Tate

Sections of Cardiovascular Sciences and Geriatrics, Baylor College of Medicine, Houston 77030; and Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204

Received 15 February 1995; accepted in final form 17 April 1996.

Taffet, George E., Lloyd A. Michael, and Charlotte A. Tate. Exercise training improves lusitropy by isoproterenol in papillary muscles from aged rats. J. Appl. Physiol. 81(4): 1488-1494, 1996.---Aging is associated with a decreased cardiac responsiveness to beta -adrenergic stimulation. We examined the effect of endurance exercise training of old Fischer 344 male rats on beta -adrenergic stimulation of the function of isolated left ventricular papillary muscle. Three groups were examined: sedentary mature (SM; 12-mo old), sedentary old (SO; 23-24 mo old), and exercised old (EO; 23-24 mo old) that were treadmill trained for 4-8 wk. The isometric contractile properties were studied at 0.2 Hz and 0.75 mM calcium. Without beta -adrenergic stimulation, there were no group differences for peak tension, maximum rate of tension development (+dP/dt), or maximum rate of tension dissipation (-dP/dt). The time to peak tension was longer (P < 0.05) for both EO and SO than for SM rats. Half relaxation time (RT1/2) was prolonged (P < 0.05) for SO compared with SM and EO (which did not differ). The three groups did not differ in the beta -adrenergic stimulation by isoproterenol of peak tension, -dP/dt, time to peak tension, or contraction duration. The inotropic response (+dP/dt) of SM was greater (P < 0.05) than that in SO or EO rats (which did not differ); however, the lusitropic response (RT1/2) was lesser (P < 0.05) in SO than in SM or EO rats (which did not differ). Thus exercise training of old rats improved the lusitropic response to isoproterenol without altering the age-associated impairment in inotropic response.

beta-adrenergic; heart; old; tension; treadmill

0161-7567/96 $5.00 Copyright © 1996 the American Physiological Society




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