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Department of Physiology III, Karolinska Institute, S-11486 Stockholm, Sweden; Copenhagen Muscle Research Centre, August Krogh Institute, DK-2200 Copenhagen N, Denmark; and Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Received 2 January 1996; accepted in final form 2 April 1996.
Hellsten, Ylva, Fred S. Apple, and Bertil Sjödin.
Effect of sprint cycle training on activities of antioxidant
enzymes in human skeletal muscle. J. Appl.
Physiol. 81(4): 1484-1487, 1996.
The effect of
intermittent sprint cycle training on the level of muscle antioxidant
enzyme protection was investigated. Resting muscle biopsies, obtained
before and after 6 wk of training and 3, 24, and 72 h after the final
session of an additional 1 wk of more frequent training, were analyzed
for activities of the antioxidant enzymes glutathione peroxidase (GPX),
glutathione reductase (GR), and superoxide dismutase (SOD). Activities
of several muscle metabolic enzymes were determined to assess the effectiveness of the training. After the first 6-wk training period, no
change in GPX, GR, or SOD was observed, but after the 7th week of
training there was an increase in GPX from 120 ± 12 (SE) to 164 ± 24 µmol · min
1 · g
dry wt1
(P < 0.05) and in GR from 10.8 ± 0.8 to 16.8 ± 2.4 µmol · min1 · g
dry wt1
(P < 0.05). There was no significant
change in SOD. Sprint cycle training induced a significant
(P < 0.05) elevation in the activity of phosphofructokinase and creatine kinase, implying an enhanced anaerobic capacity in the trained muscle. The present study
demonstrates that intermittent sprint cycle training that induces an
enhanced capacity for anaerobic energy generation also improves the
level of antioxidant protection in the muscle.
free radicals; scavengers
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