Journal of Applied Physiology
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J Appl Physiol 81: 1423-1429, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology, Vol 81, Issue 3 1423-1429, Copyright © 1996 by American Physiological Society

ARTICLES

Electrochemical nitric oxide and nitrogen dioxide analyzer for use with inhaled nitric oxide

L. D. Nelin, N. T. Christman, J. F. Morrisey and C. A. Dawson
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA.

The use of inhaled nitric oxide (NO) in research and clinical applications requires the monitoring of NO and its autooxidation product nitrogen dioxide (NO2) in inspired gas and in the ambient environment. We describe an inexpensive electrochemical NO and NO2 analyzer that uses a critical orifice constant-flow controller and a microprocessor crossover correction for the measurement of NO and NO2 in the concentration range relevant to the use of inhaled NO. The analyzer proved to have good accuracy and precision for NO and NO2 in the range of concentrations relevant to studies of inhaled NO. In this range, the performance was similar to that of a chemiluminescence analyzer, and the response characteristics were not affected by varying the O2 concentration of the mixtures analyzed.


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