Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 81: 1174-1183, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology, Vol 81, Issue 3 1174-1183, Copyright © 1996 by American Physiological Society

ARTICLES

Cerebral oxygenation changes in response to motor stimulation

H. Obrig, C. Hirth, J. G. Junge-Hulsing, C. Doge, T. Wolf, U. Dirnagl and A. Villringer
Department of Neurology, Humboldt-Universitat zu Berlin, Germany.

We studied cerebral hemodynamic response to a sequential motor task in 56 subjects to investigate the time course and distribution of blood oxygenation changes as monitored by near-infrared spectroscopy (NIRS). To address whether response is modulated by different performance velocities, a group of subjects (n = 12) was examined while performing the motor task at 1, 2, and 3 Hz. The results demonstrate that 1) the NIRS response reflects localized changes in cerebral hemodynamics, 2) the response, consisting of an increase in oxygenated hemoglobin concentration [oxy-Hb] and a decrease in deoxygenated hemoglobin concentration ([deoxy-Hb]), is lateralized and increases in amplitude with higher performance rates, and 3) changes in [oxy-Hb] and [deoxy-Hb] differ in time course. Changes in [oxy-Hb] are biphasic, with a fast initial increase and a pronounced poststimulus undershoot. The stimulus-associated decrease in [deoxy-Hb] is monophasic, and response latency is greater. We conclude that NIRS is able to detect even small changes in cerebral hemodynamic response to functional stimulation.


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