| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 81, Issue 2 830-837, Copyright © 1996 by American Physiological Society
ARTICLES |
J. F. Pittet, T. J. Brenner, K. Modelska and M. A. Matthay
Department of Anesthesia, University of California, San Francisco 94143, USA.
The primary objective of this study was to test the hypothesis that hemorrhagic shock would stimulate alveolar liquid clearance by a catecholamine-dependent mechanism. Anesthetized rats were hemorrhaged to a mean arterial pressure of 30 mmHg for 90 min, but they were not resuscitated. Alveolar liquid clearance was measured by the concentration of labeled and unlabeled protein over 2 h in an isosmolar physiological solution of 5% albumin that had been instilled into one lung. Hemorrhaged rats developed a severe metabolic acidosis that was associated with a 5- to 10-fold rise in plasma epinephrine levels. There was a 60% increase in alveolar liquid clearance in the hemorrhaged rats compared with control rats (55 +/- 6 vs. 34 +/- 7%; P < 0.05). Amiloride (10(-4) M) or propranolol (10(-4)M) inhibited the increase in alveolar liquid clearance. Thus the endogenous release of catecholamines associated with hemorrhagic shock markedly stimulates alveolar fluid clearance by a beta-adrenergic-mediated stimulation of active sodium transport. These data suggest a new, previously unrecognized mechanism that may protect against alveolar flooding in the acute phase of hemorrhagic shock.
This article has been cited by other articles:
|
|
 |
|
  X. Su, L. Robriquet, H. G. Folkesson, and M. A. Matthay Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L769 - L776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Folkesson, C. J. Chapin, L. L. Beard, R. Ertsey, M. A. Matthay, and J. A. Kitterman Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L478 - L484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sartori and M.A. Matthay Alveolar epithelial fluid transport in acute lung injury: new insights Eur. Respir. J., November 1, 2002; 20(5): 1299 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Matthay, H. G. Folkesson, and C. Clerici Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema Physiol Rev, July 1, 2002; 82(3): 569 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J F Pittet, L N Lu, T Geiser, H Lee, M A Matthay, and W J Welch Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats J. Physiol., January 15, 2002; 538(2): 583 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. McGraw, N. Fukuda, P. F. James, S. L. Forbes, A. L. Woo, J. B. Lingrel, D. P. Witte, M. A. Matthay, and S. B. Liggett Targeted transgenic expression of {beta}2-adrenergic receptors to type II cells increases alveolar fluid clearance Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L895 - L903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Chesnutt, T. J. Nuckton, J. Golden, H. G. Folkesson, and M. A. Matthay Rapid Alveolar Epithelial Fluid Clearance Following Lung Lavage in Pulmonary Alveolar Proteinosis Chest, July 1, 2001; 120(1): 271 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-F. Pittet, L. N. Lu, D. G. Morris, K. Modelska, W. J. Welch, H. V. Carey, J. Roux, and M. A. Matthay Reactive Nitrogen Species Inhibit Alveolar Epithelial Fluid Transport After Hemorrhagic Shock in Rats J. Immunol., May 15, 2001; 166(10): 6301 - 6310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. CRANDALL and M. A. MATTHAY Alveolar Epithelial Transport . Basic Science to Clinical Medicine Am. J. Respir. Crit. Care Med., March 15, 2001; 163(4): 1021 - 1029. [Full Text]
|
|
|
|
 |
|
 Z. S. Azzam, F. J. Saldias, A. Comellas, K. M. Ridge, D. H. Rutschman, and J. I. Sznajder Catecholamines increase lung edema clearance in rats with increased left atrial pressure J Appl Physiol, March 1, 2001; 90(3): 1088 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Frank, Y. Wang, O. Osorio, and M. A. Matthay beta -Adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats J Appl Physiol, October 1, 2000; 89(4): 1255 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Folkesson, A. Norlin, Y. Wang, P. Abedinpour, and M. A. Matthay Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats J Appl Physiol, February 1, 2000; 88(2): 416 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, H. G. Folkesson, C. Jayr, L. B. Ware, and M. A. Matthay Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta -agonist therapy J Appl Physiol, November 1, 1999; 87(5): 1852 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. MODELSKA, J.-F. PITTET, H. G. FOLKESSON, V. COURTNEY BROADDUS, and M. A. MATTHAY Acid-induced Lung Injury . Protective Effect of Anti-interleukin-8 Pretreatment on Alveolar Epithelial Barrier Function in Rabbits Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): 1450 - 1456. [Abstract] [Full Text]
|
|
|
|
|
|
G. M. Verghese, L. B. Ware, B. A. Matthay, and M. A. Matthay Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema J Appl Physiol, October 1, 1999; 87(4): 1301 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. LOIS, L. A. S. BROWN, I. M. MOSS, J. ROMAN, and D. M. GUIDOT Ethanol Ingestion Increases Activation of Matrix Metalloproteinases in Rat Lungs during Acute Endotoxemia Am. J. Respir. Crit. Care Med., October 1, 1999; 160(4): 1354 - 1360. [Abstract] [Full Text]
|
|
|
|
|
|
M. Laffon, L. N. Lu, K. Modelska, M. A. Matthay, and J. F. Pittet alpha -Adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L760 - L768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Charron, J. P. Fawley, and M. B. Maron Effect of epinephrine on alveolar liquid clearance in the rat J Appl Physiol, August 1, 1999; 87(2): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Modelska, M. A. Matthay, L. A. S. Brown, E. Deutch, L. N. Lu, and J. F. Pittet Inhibition of beta -adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L844 - L857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Maron Dose-response relationship between plasma epinephrine concentration and alveolar liquid clearance in dogs J Appl Physiol, November 1, 1998; 85(5): 1702 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. LANE, K. C. MAENDER, N. E. AWENDER, and M. B. MARON Adrenal Epinephrine Increases Alveolar Liquid Clearance in a Canine Model of Neurogenic Pulmonary Edema Am. J. Respir. Crit. Care Med., September 1, 1998; 158(3): 760 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Folkesson, G. Nitenberg, B. L. Oliver, C. Jayr, K. H. Albertine, and M. A. Matthay Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin Am J Physiol Lung Cell Mol Physiol, September 1, 1998; 275(3): L478 - L490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Garat, E. P. Carter, and M. A. Matthay New in situ mouse model to quantify alveolar epithelial fluid clearance J Appl Physiol, May 1, 1998; 84(5): 1763 - 1767. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
