Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 81: 1027-1032, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hess, P.
Right arrow Articles by Clozel, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hess, P.
Right arrow Articles by Clozel, J. P.

Journal of Applied Physiology, Vol 81, Issue 2 1027-1032, Copyright © 1996 by American Physiological Society

ARTICLES

Telemetry monitoring of pulmonary arterial pressure in freely moving rats

P. Hess, M. Clozel and J. P. Clozel
Pharma Division, F. Hoffmann-La Roche, Basel, Switzerland.

Several rat models of pulmonary hypertension have been developed. However, up until now it has been difficult to monitor pulmonary arterial pressure for long periods of time. The goal of the present study was to develop a telemetry system allowing chronic monitoring of pulmonary arterial pressure in freely moving rats. For this purpose, while animals were under anesthesia, a sensing catheter was implanted into the pulmonary arterial trunk through the right ventricle. This catheter was connected to an emitter implanted in the abdomen. Validation of the system was performed in three steps. First, acutely, we controlled that the pressure signal transmitted by the telemetry system was accurate and corresponded to a signal obtained with a high-fidelity Millar catheter. Second, we evaluated the chronic consequences of implantation of the system. Third, we used the system to monitor pulmonary arterial pressure in a model of monocrotaline-induced hypertension in which the effects of bosentan, an endothelin-receptor antagonist, were evaluated. The telemetry system was reliable and did not lead to damage of the right ventricle and/or to chronic pulmonary embolism. After a recovery period of 8-10 days, mean pulmonary arterial pressure was stable. With the use of this telemetry system, it was possible to follow the increase of pulmonary arterial pressure induced by monocrotaline. In this model, bosentan decreased mean pulmonary arterial pressure by 13% (P = 0.07), suggesting a role of endothelin in this model of pulmonary hypertension. We conclude that it is possible to use this telemetry system to monitor pulmonary arterial pressure in freely moving conscious rats.


This article has been cited by other articles:


Home page
 ChestHome page
R. Syyed, J. T. Reeves, D. Welsh, D. Raeside, M. K. Johnson, and A. J. Peacock
The Relationship Between the Components of Pulmonary Artery Pressure Remains Constant Under All Conditions in Both Health and Disease
Chest, March 1, 2008; 133(3): 633 - 639.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
P. Pokreisz, G. Marsboom, and S. Janssens
Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited
Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H75 - H84.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Akhavein, E. J. St.-Michel, E. Seifert, and C. V. Rohlicek
Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats
J Appl Physiol, July 1, 2007; 103(1): 287 - 295.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. Clozel, P. Hess, M. Rey, M. Iglarz, C. Binkert, and C. Qiu
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.
Experimental Biology and Medicine, June 1, 2006; 231(6): 967 - 973.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Sebkhi, J. W. Strange, S. C. Phillips, J. Wharton, and M. R. Wilkins
Phosphodiesterase Type 5 as a Target for the Treatment of Hypoxia-Induced Pulmonary Hypertension
Circulation, July 1, 2003; 107(25): 3230 - 3235.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
F. Brunner, G. Wolkart, and S. Haleen
Defective Intracellular Calcium Handling in Monocrotaline-Induced Right Ventricular Hypertrophy: Protective Effect of Long-Term Endothelin-A Receptor Blockade with 2-Benzo[1,3]dioxol-5-yl-3-benzyl-4-(4-methoxy-phenyl-)- 4-oxobut-2-enoate-sodium (PD 155080)
J. Pharmacol. Exp. Ther., February 1, 2002; 300(2): 442 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. M. El-Mas and A. A. Abdel-Rahman
Radiotelemetric Evaluation of Hemodynamic Effects of Long-Term Ethanol in Spontaneously Hypertensive and Wistar-Kyoto Rats
J. Pharmacol. Exp. Ther., March 1, 2000; 292(3): 944 - 951.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
N. S. Hill, R. R. Warburton, L. Pietras, and J. R. Klinger
Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats
J Appl Physiol, October 1, 1997; 83(4): 1209 - 1215.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online