Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 80: 2211-2216, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Armour, C. L.
Right arrow Articles by Black, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Armour, C. L.
Right arrow Articles by Black, J. L.

Journal of Applied Physiology, Vol 80, Issue 6 2211-2216, Copyright © 1996 by American Physiological Society

ARTICLES

Does the disease state influence the responsiveness of human airways studied in vitro?

C. L. Armour, K. O. McKay, P. R. Johnson, A. R. Glanville and J. L. Black
Department of Pharmacy, University of Sydney, Australia.

Human airway tissue has been used in vitro to study mechanisms of airway disease. However, there has never been a comprehensive study that has looked at the influence of disease on the subsequent in vitro responsiveness of human airways. In this study, we obtained airway tissue from patients who were undergoing resection of the lung for carcinoma. We then compared the airway responsiveness in these tissues and in tissues from patients who had undergone lung transplantation for alpha-1-antitrypsin deficiency, emphysema, or cystic fibrosis with the responsiveness in tissues obtained from donor lungs, i.e., nondiseased. When the relationships between concentration and response were compared, we found that for histamine, electrical field stimulation, levcromakalim, and isoproterenol similar responses could be expected in tissues obtained from all the sources studied. This was not true for acetylcholine in that there were significantly lower responses in tissues from patients with alpha-1-antitrypsin deficiency (P = 0.02; n = 9) or from patients having a lung resected for carcinoma (P = 0.01; n = 6) compared with that of the nondiseased group (n = 6). Similarly, for carbachol, the responses were significantly lower in the alpha-1-antitrypsin deficiency group (P = 0.001; n = 10) and in specimens resected for carcinoma (P = 0.001; n = 6) than in the nondiseased group (n = 9). We conclude that, apart from acetylcholine and carbachol, contractile and relaxant agonists give similar responses when used in human airway tissues from various sources. Our results highlight the importance of stating the source of tissue when human airways are to be studied.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
F.-X. Blanc, S. Salmeron, C. Coirault, M. Bard, E. Fadel, E. Dulmet, P. Dartevelle, and Y. Lecarpentier
Effects of load and tone on the mechanics of isolated human bronchial smooth muscle
J Appl Physiol, February 1, 1999; 86(2): 488 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. O. MCKAY, P. R. A. JOHNSON, J. L. BLACK, A. R. GLANVILLE, and C. L. ARMOUR
Airway Structure and Function in Eisenmenger's Syndrome
Am. J. Respir. Crit. Care Med., October 1, 1998; 158(4): 1245 - 1252.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online