| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 80, Issue 5 1605-1611, Copyright © 1996 by American Physiological Society
ARTICLES |
P. A. Hansen, T. J. McCarthy, E. N. Pasia, R. J. Spina and E. A. Gulve
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
The present study examined the effects of 6 wk of ovarian endocrine deficiency on skeletal muscle GLUT-4 glucose transporter protein and glucose transport activity in sedentary and endurance-trained rats. Female Wistar rats (10 wk old) underwent bilateral ovariectomy (OVX) or sham surgery followed by a 5-wk swim-training protocol. OVX resulted in no significant changes in glycogen or GLUT-4 glucose transporter concentration in the soleus, epitrochlearis, or flexor digitorum brevis (FDB) muscles or in basal and maximally insulin-stimulated 2-deoxy-D-[1,2-3H]glucose (2-[3H]DG) transport in the soleus or epitrochlearis, suggesting that moderate-duration ovarian hormone deficiency does not significantly impair insulin action in skeletal muscle. In contrast, OVX decreased the maximal activation of 2-[3H]DG transport in the FDB by in vitro electrical stimulation. OVX had no significant effect on the training-induced changes in oxidative enzyme activities, GLUT-4 protein expression, glycogen content, or insulin-stimulated 2-[3H]DG transport in the soleus or epitrochlearis. These findings provide the first evidence that ovarian hormone deficiency decreases contraction-stimulated glucose transport in skeletal muscle.
This article has been cited by other articles:
|
|
 |
|
  M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, and T. Miyauchi Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1290 - H1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, T. Miyauchi, S. Maeda, T. Tanabe, M. Takanashi, M. Matsuda, and I. Yamaguchi Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1696 - H1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Garcia-Roves, D.-H. Han, Z. Song, T. E. Jones, K. A. Hucker, and J. O. Holloszy Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise Am J Physiol Endocrinol Metab, October 1, 2003; 285(4): E729 - E736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. D'Eon, C. Sharoff, S. R. Chipkin, D. Grow, B. C. Ruby, and B. Braun Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E1046 - E1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Suh, G. A. Casazza, M. A. Horning, B. F. Miller, and G. A. Brooks Luteal and follicular glucose fluxes during rest and exercise in 3-h postabsorptive women J Appl Physiol, July 1, 2002; 93(1): 42 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Campbell and M. A. Febbraio Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E1139 - E1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Ruby, A. R. Coggan, and T. W. Zderic Gender differences in glucose kinetics and substrate oxidation during exercise near the lactate threshold J Appl Physiol, March 1, 2002; 92(3): 1125 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Tarnopolsky, C. Zawada, L. B. Richmond, S. Carter, J. Shearer, T. Graham, and S. M. Phillips Gender differences in carbohydrate loading are related to energy intake J Appl Physiol, July 1, 2001; 91(1): 225 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Zderic, A. R. Coggan, and B. C. Ruby Glucose kinetics and substrate oxidation during exercise in the follicular and luteal phases J Appl Physiol, February 1, 2001; 90(2): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Latour, M. Shinoda, and J.-M. Lavoie Metabolic effects of physical training in ovariectomized and hyperestrogenic rats J Appl Physiol, January 1, 2001; 90(1): 235 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Ojuka, L. A. Nolte, and J. O. Holloszy Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro J Appl Physiol, March 1, 2000; 88(3): 1072 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Fisher, W. M. Kohrt, and M. Brown Food restriction suppresses muscle growth and augments osteopenia in ovariectomized rats J Appl Physiol, January 1, 2000; 88(1): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Greiwe, R. C. Hickner, P. A. Hansen, S. B. Racette, M. M. Chen, and J. O. Holloszy Effects of endurance exercise training on muscle glycogen accumulation in humans J Appl Physiol, July 1, 1999; 87(1): 222 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawanaka, D.-H. Han, L. A. Nolte, P. A. Hansen, A. Nakatani, and J. O. Holloszy Decreased insulin-stimulated GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E907 - E912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Kim, L. A. Nolte, P. A. Hansen, D.-H. Han, K. Kawanaka, and J. O. Holloszy Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R665 - R672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Host, P. A. Hansen, L. A. Nolte, M. M. Chen, and J. O. Holloszy Glycogen supercompensation masks the effect of a traininginduced increase in GLUT-4 on muscle glucose transport J Appl Physiol, July 1, 1998; 85(1): 133 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Host, P. A. Hansen, L. A. Nolte, M. M. Chen, and J. O. Holloszy Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation J Appl Physiol, March 1, 1998; 84(3): 798 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Hansen, D. H. Han, L. A. Nolte, M. Chen, and J. O. Holloszy DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1704 - R1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Hickner, J. S. Fisher, P. A. Hansen, S. B. Racette, C. M. Mier, M. J. Turner, and J. O. Holloszy Muscle glycogen accumulation after endurance exercise in trained and untrained individuals J Appl Physiol, September 1, 1997; 83(3): 897 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nakatani, D.-H. Han, P. A. Hansen, L. A. Nolte, H. H. Host, R. C. Hickner, and J. O. Holloszy Effect of endurance exercise training on muscle glycogen supercompensation in rats J Appl Physiol, February 1, 1997; 82(2): 711 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Horton, E. K. Miller, D. Glueck, and K. Tench No effect of menstrual cycle phase on glucose kinetics and fuel oxidation during moderate-intensity exercise Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E752 - E762. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
