Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 80: 1485-1489, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Numa, A. H.
Right arrow Articles by Newth, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Numa, A. H.
Right arrow Articles by Newth, C. J.

Journal of Applied Physiology, Vol 80, Issue 5 1485-1489, Copyright © 1996 by American Physiological Society

ARTICLES

Anatomic dead space in infants and children

A. H. Numa and C. J. Newth
Division of Pediatric Critical Care, Children's Hospital Los Angeles, University of Southern California 90027, USA.

In adults, anatomic dead space is 2.2 ml/kg. Because of the relatively large head size of infants and children, we hypothesized that extrathoracic and, therefore, total dead space would be relatively larger in pediatric subjects. Extrathoracic dead space was measured by a "water displacement" technique in 40 patients aged 7 days to 14.2 yr who were intubated with cuffed endotracheal tubes. Intrathoracic dead space was measured by continuous analysis of end-tidal and mixed-expired PCO2 and minute ventilation in 10 patients, aged 18 days to 14.7 yr. Extrathoracic dead space per kilogram decreased exponentially with increasing age, ranging from 2.3 ml/kg in early infancy to 0.8 ml/kg in children older than 6 yr. Mean intrathoracic anatomic dead space was 1.03 ml/kg and was not related to age. The following relationship between total anatomic dead space (DStotal; in ml/kg) and age (in yr) is derived: DStotal = 3.28 - 0.56 [ln(1 + Age)], with r = 0.95 and P = 0.0001. Anatomic dead space is age dependent and is > 3 ml/kg in early infancy.


This article has been cited by other articles:


Home page
 PediatricsHome page
Z. C. Reyes, N. Claure, M. K. Tauscher, C. D'Ugard, S. Vanbuskirk, and E. Bancalari
Randomized, Controlled Trial Comparing Synchronized Intermittent Mandatory Ventilation and Synchronized Intermittent Mandatory Ventilation Plus Pressure Support in Preterm Infants
Pediatrics, October 1, 2006; 118(4): 1409 - 1417.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. L. Zeman and W. D. Bennett
Growth of the small airways and alveoli from childhood to the adult lung measured by aerosol-derived airway morphometry
J Appl Physiol, March 1, 2006; 100(3): 965 - 971.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
G Dimitriou, A Greenough, V Kavvadia, B Laubscher, and A D Milner
Volume delivery during high frequency oscillation
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 1998; 78(2): 148F - 150.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online