Journal of Applied Physiology AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 80: 899-903, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Forner, M. A.
Right arrow Articles by Ortega, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Forner, M. A.
Right arrow Articles by Ortega, E.

Journal of Applied Physiology, Vol 80, Issue 3 899-903, Copyright © 1996 by American Physiological Society

ARTICLES

Exercise-induced stimulation of murine macrophage phagocytosis may be mediated by thyroxine

M. A. Forner, C. Barriga and E. Ortega
Department of Animal Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain.

The present study was designed to test the hypothesis that changes in plasma concentrations of hormones may be responsible for the exercise-induced macrophage phagocytic stimulation. The effect of 30-min incubation of macrophages with plasma from mice previously exposed to swimming until exhaustion (with or without previous training) was studied, and the results showed a similar stimulation of the phagocytic capacity (attachment and ingestion) of these cells to that found in previous studies after exercise. Also, changes in plasma concentration of both thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) after exercise were measured, and their effect on phagocytic capacity after in vitro incubation with peritoneal macrophages was investigated. Results indicated that, after exercise, plasma concentrations of T3 and T4 increased. Incubation of peritoneal macrophages for 30 min with a concentration of T3 similar to that observed in the plasma immediately after exercise (1.5 ng/ml) induced no modifications in the phagocytic capacity. However, a physiological concentration of T4 after exercise (75 ng/ml) stimulated the phagocytic capacity of peritoneal macrophages. In addition, a 10,000-fold greater concentration of these thyroid hormones did not modify the macrophage function. It is concluded that physiological concentration of T4 may be a mediator of the stimulation of the phagocytic function in macrophages induced by exercise.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
S.-H. Su, H.-i. Chen, and C. J. Jen
C57BL/6 and BALB/c Bronchoalveolar Macrophages Respond Differently to Exercise
J. Immunol., November 1, 2001; 167(9): 5084 - 5091.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. O. Rincon, J. M. Marchena, J. J. Garcia, A. Schmidt, T. Schulz, I. Malpica, A. B. Rodriguez, C. Barriga, H. Michna, and H. Lotzerich
Phagocytic function in cyclists: correlation with catecholamines and cortisol
J Appl Physiol, September 1, 2001; 91(3): 1067 - 1072.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online