Journal of Applied Physiology Millar Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 80: 810-817, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Overgaard, C. B.
Right arrow Articles by Jennings, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Overgaard, C. B.
Right arrow Articles by Jennings, D. B.

Journal of Applied Physiology, Vol 80, Issue 3 810-817, Copyright © 1996 by American Physiological Society

ARTICLES

Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks

C. B. Overgaard, J. K. Walker and D. B. Jennings
Department of Physiology, Queen's University, Kingston, Ontario, Canada.

In normoxic conscious dogs, increased angiotensin II (ANG II), or activation (disinhibition) of the renin-angiotensin system by vasopressin (AVP) V1-receptor block, increases ventilation and decreases arterial PCO2. Both hormones can be increased during hypoxia and might modulate ventilatory drive. Six conscious dogs were studied before and during hypocapnic, isocapnic, and hypercapnic hypoxia. To study potential hormonal effects during hypocapnic hypoxia, experiment 1 included three protocols in which 12.8% O2 was breathed for 60 min: protocol 1, control studies without block; protocol 2, AVP V1 receptors were blocked at the onset of hypoxia; and protocol 3, ANG II receptors were blocked 20 min before hypoxia. To study potential effects of acid-base changes during acute hypoxia, experiment 2 included two protocols (with and without AVP V1-receptor block). A 40-min period of hypocapnic hypoxia was followed by two successive 20-min periods with hypoxia maintained but inspired CO2 progressively increased. Neither hormonal block affected respiration during the hypoxic conditions. Unlike normoxia in conscious dogs, during acute hypoxia, respiratory control by ANG II is not modulated by AVP and acid-base effects on receptors do not account for this difference.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. A. Steiner, E. C. Carnio, J. Antunes-Rodrigues, and L. G. S. Branco
Endogenous vasopressin does not mediate hypoxia-induced anapyrexia in rats
J Appl Physiol, February 1, 1999; 86(2): 469 - 473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. J. Heitman and D. B. Jennings
Angiotensin II modulates respiratory and acid-base responses to prolonged hypoxia in conscious dogs
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R390 - R399.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online