| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 80, Issue 2 369-387, Copyright © 1996 by American Physiological Society
ARTICLES |
B. B. Rubin, A. Romaschin, P. M. Walker, D. C. Gute and R. J. Korthuis
R. Fraser Elliott Vascular Research Laboratory, The Toronto Hospital, Ontario, Canada.
Reperfusion of ischemic skeletal muscle leads to adverse local and systemic effects. These detrimental effects may be attenuated by interfering with or modulating the pathophysiological processes that are set in motion during ischemia and/or reperfusion. The purpose of this paper is to review the different intervention strategies that have been employed in an attempt to elucidate the mechanisms involved in the pathogenesis of skeletal muscle ischemia-reperfusion injury. The results of these studies indicate that the postischemic injury processes that lead to cell dysfunction and death are multifactorial in nature and include oxidant generation, elaboration of proinflammatory mediators, infiltration of leukocytes, Ca2+ overload, phospholipid peroxidation and depletion, impaired nitric oxide metabolism, and reduced ATP production. Although the etiopathogenesis of skeletal muscle ischemia-reperfusion is complex, careful delineation of the mechanisms that contribute to postischemic microvascular dysfunction and muscle necrosis has progressed to the point where rational intervention strategies may be proposed and implemented as potential treatments for skeletal muscle dysfunction associated with ischemia-reperfusion.
This article has been cited by other articles:
|
|
 |
|
  S. E. McAllister, H. Ashrafpour, N. Cahoon, N. Huang, M. A. Moses, P. C. Neligan, C. R. Forrest, J. E. Lipa, and C. Y. Pang Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R681 - R689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Carles, J. Dellamonica, J. Roux, D. Lena, J. Levraut, J. F. Pittet, P. Boileau, and M. Raucoules-Aime Sevoflurane but not propofol increases interstitial glycolysis metabolites availability during tourniquet-induced ischaemia reperfusion Br. J. Anaesth., January 1, 2008; 100(1): 29 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-D. Schaser, A. C. Disch, J. F. Stover, A. Lauffer, H. J. Bail, and T. Mittlmeier Prolonged Superficial Local Cryotherapy Attenuates Microcirculatory Impairment, Regional Inflammation, and Muscle Necrosis After Closed Soft Tissue Injury in Rats Am. J. Sports Med., January 1, 2007; 35(1): 93 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Martou, C. A. O'Blenes, N. Huang, S. E. McAllister, P. C. Neligan, H. Ashrafpour, C. Y. Pang, and J. E. Lipa Development of an in vitro model for study of the efficacy of ischemic preconditioning in human skeletal muscle against ischemia-reperfusion injury J Appl Physiol, November 1, 2006; 101(5): 1335 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mithoefer, D. W. Lhowe, M. S. Vrahas, D. T. Altman, V. Erens, and G. T. Altman Functional Outcome After Acute Compartment Syndrome of the Thigh J. Bone Joint Surg. Am., April 1, 2006; 88(4): 729 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Moses, P. D. Addison, P. C. Neligan, H. Ashrafpour, N. Huang, S. E. McAllister, J. E. Lipa, C. R. Forrest, and C. Y. Pang Inducing late phase of infarct protection in skeletal muscle by remote preconditioning: efficacy and mechanism Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1609 - R1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. X Pizza, J. M Peterson, J. H Baas, and T. J Koh Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice J. Physiol., February 1, 2005; 562(3): 899 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Tupling, A. O. Gramolini, T. A. Duhamel, H. Kondo, M. Asahi, S. C. Tsuchiya, M. J. Borrelli, J. R. Lepock, K. Otsu, M. Hori, et al. HSP70 Binds to the Fast-twitch Skeletal Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA1a) and Prevents Thermal Inactivation J. Biol. Chem., December 10, 2004; 279(50): 52382 - 52389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yuceyar, H. Erolcay, D. Konukoglu, A. K. Bozkurt, and B. Aykac Epidural anesthesia may attenuate lipid peroxidation during aorto-femoral surgery: [L'anesthesie peridurale peut diminuer la peroxydation lipidique pendant une intervention chirurgicale aorto-femorale] Can J Anesth, May 1, 2004; 51(5): 465 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Addison, P. C. Neligan, H. Ashrafpour, A. Khan, A. Zhong, M. Moses, C. R. Forrest, and C. Y. Pang Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1435 - H1443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. McLoughlin, E. Mylona, T. A. Hornberger, K. A. Esser, and F. X. Pizza Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions J Appl Physiol, March 1, 2003; 94(3): 876 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Spies, M. R. K. Dasu, N. Svrakic, O. Nesic, R. E. Barrow, J. R. Perez-Polo, and D. N. Herndon Gene expression analysis in burn wounds of rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R918 - R930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tupling, H. Green, G. Senisterra, J. Lepock, and N. McKee Ischemia-induced structural change in SR Ca2+-ATPase is associated with reduced enzyme activity in rat muscle Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1681 - R1688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Stupka and P. M. Tiidus Effects of ovariectomy and estrogen on ischemia-reperfusion injury in hindlimbs of female rats J Appl Physiol, October 1, 2001; 91(4): 1828 - 1835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Tupling, H. Green, G. Senisterra, J. Lepock, and N. McKee Effects of 4-h ischemia and 1-h reperfusion on rat muscle sarcoplasmic reticulum function Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E867 - E877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tupling, H. Green, G. Senisterra, J. Lepock, and N. McKee Effects of ischemia on sarcoplasmic reticulum Ca2+ uptake and Ca2+ release in rat skeletal muscle Am J Physiol Endocrinol Metab, August 1, 2001; 281(2): E224 - E232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kohin, C. M. Stary, R. A. Howlett, and M. C. Hogan Preconditioning improves function and recovery of single muscle fibers during severe hypoxia and reoxygenation Am J Physiol Cell Physiol, July 1, 2001; 281(1): C142 - C146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tupling, H. Green, S. Grant, M. Burnett, and D. Ranney Postcontractile force depression in humans is associated with an impairment in SR Ca2+ pump function Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R87 - R94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mohanraj, A. J. Merola, V. P. Wright, and T. L. Clanton Antioxidants protect rat diaphragmatic muscle function under hypoxic conditions J Appl Physiol, June 1, 1998; 84(6): 1960 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. X. Pizza, T. J. Koh, S. J. McGregor, and S. V. Brooks Muscle inflammatory cells after passive stretches, isometric contractions, and lengthening contractions J Appl Physiol, May 1, 2002; 92(5): 1873 - 1878. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
