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J Appl Physiol 80: 166-175, 1996;
8750-7587/96 $5.00
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Journal of Applied Physiology, Vol 80, Issue 1 166-175, Copyright © 1996 by American Physiological Society

ARTICLES

Rebound increase in fetal breathing movements after 24-h prostaglandin E2 infusion in fetal sheep

S. A. Hollingworth, S. A. Jones and S. L. Adamson
Program in Development and Fetal Health, Mount Sinai Hospital, Toronto, Canada.

We investigated the hypothesis that the precipitous decrease in prostaglandin E2 (PGE2), a potent inhibitor of fetal breathing, from high plasma concentrations during labor causes a rebound stimulation of breathing without newborn concentrations falling below prelabor fetal values. Fetal plasma PGE2 concentration was gradually increased from 384 +/- 82 (SE) pg/ml in 2-h steps [0 (baseline), 1.5, 3, and 6 micrograms/min] to labor levels (1,230 +/- 381 pg/ml at 6 micrograms/min) and then was maintained for 24 h (n = 9). PGE2 at 1.5 micrograms/min significantly decreased breathing incidence [from 42 +/- 4 (baseline) to 14 +/- 4%] and breath amplitude (from 2.1 +/- 0.5 to 1.5 +/- 0.2 arbitrary units) and increased breath-to-breath interval (from 1.16 +/- 0.07 to 1.56 +/- 0.06 s). No further dose-related changes were observed. During the first 2 h after PGE2 infusion was stopped, PGE2 concentration returned to basal (352 +/- 64 pg/ml) but breathing incidence and amplitude were significantly higher (74 +/- 8% and 2.4 +/- 0.3 arbitrary units, respectively) and breath-to-breath interval was significantly lower (0.95 +/- 0.10 s) than were basal levels. Changes arose within approximately 15 min and were maintained for at least 4 h. Breathing did not change significantly in the saline-treated group (n = 7). Results suggest that the rapid decrease in plasma PGE2 concentration at birth promotes the onset of breathing.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. C. Tai and S. L. Adamson
Developmental changes in respiratory, febrile, and cardiovascular responses to PGE2 in newborn lambs
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1460 - R1473.
[Abstract] [Full Text] [PDF]


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