Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 80: 108-115, 1996;
8750-7587/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bernard, D. G.
Right arrow Articles by Nattie, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernard, D. G.
Right arrow Articles by Nattie, E. E.

Journal of Applied Physiology, Vol 80, Issue 1 108-115, Copyright © 1996 by American Physiological Society

ARTICLES

Evidence for central chemoreception in the midline raphe

D. G. Bernard, A. Li and E. E. Nattie
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA.

We injected acetazolamide (AZ; 5 x 10(-6) M; 1 nl; n = 14), its inactive analogue 2-acetylamino-1,3,4-thiadiazole-5-sulfon-t-butylamide (5 x 10(-5) M; n = 6), or mock cerebrospinal fluid (n = 5) into the caudal raphe in the midline brain stem of anesthetized paralyzed ventilated rats. These AZ injections have been shown to produce a focal region of tissue acidosis with a radius < 350 microns and are used as a probe for sites of central chemosensitivity. Compared with control injections, AZ injection into the raphe, as demonstrated by anatomic analysis of injection location, significantly increased the amplitude of the integrated phrenic neurogram over 10-40 min. Not all raphe injections produced such a response. AZ injections identified as responders (n = 8 of 14) increased integrated phrenic amplitude 43.3 +/- 10.7% (SE) of baseline 20 min after the injection. We conclude that the midline caudal raphe contains sites of ventilatory chemoreception.


This article has been cited by other articles:


Home page
 Phil Trans R Soc BHome page
S. C. Nuding, L. S. Segers, R. Shannon, R. O'Connor, K. F. Morris, and B. G. Lindsey
Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphe-pontomedullary respiratory network
Phil Trans R Soc B, September 12, 2009; 364(1529): 2501 - 2516.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. C. Nuding, L. S. Segers, D. M. Baekey, T. E. Dick, I. C. Solomon, R. Shannon, K. F. Morris, and B. G. Lindsey
Pontine-Ventral Respiratory Column Interactions Through Raphe Circuits Detected Using Multi-Array Spike Train Recordings
J Neurophysiol, June 1, 2009; 101(6): 2943 - 2960.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. L. Krause, H. V. Forster, S. E. Davis, T. Kiner, J. M. Bonis, L. G. Pan, and B. Qian
Focal acidosis in the pre-Botzinger complex area of awake goats induces a mild tachypnea
J Appl Physiol, January 1, 2009; 106(1): 241 - 250.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. M. Johnson, M. A. Haxhiu, and G. B. Richerson
GFP-expressing locus ceruleus neurons from Prp57 transgenic mice exhibit CO2/H+ responses in primary cell culture
J Appl Physiol, October 1, 2008; 105(4): 1301 - 1311.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. B. Dias, A. Li, and E. Nattie
Focal CO2 dialysis in raphe obscurus does not stimulate ventilation but enhances the response to focal CO2 dialysis in the retrotrapezoid nucleus
J Appl Physiol, July 1, 2008; 105(1): 83 - 90.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. B. Dias, T. B. Nucci, L. O. Margatho, J. Antunes-Rodrigues, L. H. Gargaglioni, and L. G. S. Branco
Raphe magnus nucleus is involved in ventilatory but not hypothermic response to CO2
J Appl Physiol, November 1, 2007; 103(5): 1780 - 1788.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. R. Noronha-de-Souza, K. C. Bicego, G. Michel, M. L. Glass, L. G. S. Branco, and L. H. Gargaglioni
Locus coeruleus is a central chemoreceptive site in toads
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R997 - R1006.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Hodges, C. Opansky, B. Qian, S. Davis, J. Bonis, J. Bastasic, T. Leekley, L. G. Pan, and H. V. Forster
Transient attenuation of CO2 sensitivity after neurotoxic lesions in the medullary raphe area of awake goats
J Appl Physiol, December 1, 2004; 97(6): 2236 - 2247.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Hodges, P. Martino, S. Davis, C. Opansky, L. G. Pan, and H. V. Forster
Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats
J Appl Physiol, December 1, 2004; 97(6): 2303 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. W. Putnam, J. A. Filosa, and N. A. Ritucci
Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1493 - C1526.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Taylor, A. Li, A. Green, H. C. Kinney, and E. E. Nattie
Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2
J Appl Physiol, November 1, 2004; 97(5): 1763 - 1773.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. A. Verner, A. K. Goodchild, and P. M. Pilowsky
A mapping study of cardiorespiratory responses to chemical stimulation of the midline medulla oblongata in ventilated and freely breathing rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R411 - R421.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Hodges, L. Klum, T. Leekley, D. T. Brozoski, J. Bastasic, S. Davis, J. M. Wenninger, T. R. Feroah, L. G. Pan, and H. V. Forster
Effects on breathing in awake and sleeping goats of focal acidosis in the medullary raphe
J Appl Physiol, May 1, 2004; 96(5): 1815 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. L. Messier, A. Li, and E. E. Nattie
Inhibition of medullary raphe serotonergic neurons has age-dependent effects on the CO2 response in newborn piglets
J Appl Physiol, May 1, 2004; 96(5): 1909 - 1919.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. E. Taylor, M. B. Harris, J. C. Leiter, and M. J. Gdovin
Ontogeny of central CO2 chemoreception: chemosensitivity in the ventral medulla of developing bullfrogs
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1461 - R1472.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. V. Forster
Plasticity in Respiratory Motor Control: Invited Review: Plasticity in the control of breathing following sensory denervation
J Appl Physiol, February 1, 2003; 94(2): 784 - 794.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Baekey, K. F. Morris, S. C. Nuding, L. S. Segers, B. G. Lindsey, and R. Shannon
Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat
J Appl Physiol, January 1, 2003; 94(1): 93 - 100.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Okada, Z. Chen, W. Jiang, S.-I. Kuwana, and F. L. Eldridge
Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats
J Appl Physiol, August 1, 2002; 93(2): 427 - 439.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
W. Wang, S. R. Bradley, and G. B Richerson
Quantification of the response of rat medullary raphe neurones to independent changes in pHo and PCO2
J. Physiol., May 1, 2002; 540(3): 951 - 970.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. P. Washburn, J. E. Sirois, E. M. Talley, P. G. Guyenet, and D. A. Bayliss
Serotonergic Raphe Neurons Express TASK Channel Transcripts and a TASK-Like pH- and Halothane-Sensitive K+ Conductance
J. Neurosci., February 15, 2002; 22(4): 1256 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Xu, Z. Zhang, and D. T. Frazier
Microinjection of acetazolamide into the fastigial nucleus augments respiratory output in the rat
J Appl Physiol, November 1, 2001; 91(5): 2342 - 2350.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Wenninger, L. G. Pan, P. Martino, L. Geiger, M. Hodges, A. Serra, T. R. Feroah, and H. V. Forster
Multiple rostral medullary nuclei can influence breathing in awake goats
J Appl Physiol, August 1, 2001; 91(2): 777 - 788.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
H. Philippi, I. Bieber, and B. Reitter
Acetazolamide Treatment for Infantile Central Sleep Apnea
J Child Neurol, August 1, 2001; 16(8): 600 - 603.
[Abstract] [PDF]

Home page
 J. Neurophysiol.Home page
W. Wang, J. K. Tiwari, S. R. Bradley, R. V. Zaykin, and G. B. Richerson
Acidosis-Stimulated Neurons of the Medullary Raphe Are Serotonergic
J Neurophysiol, May 1, 2001; 85(5): 2224 - 2235.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. E. Nattie and A. Li
CO2 dialysis in the medullary raphe of the rat increases ventilation in sleep
J Appl Physiol, April 1, 2001; 90(4): 1247 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. S. Torgerson, M. J. Gdovin, and J. E. Remmers
Sites of respiratory rhythmogenesis during development in the tadpole
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R913 - R920.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. S. Torgerson, M. J. Gdovin, R. Brandt, and J. E. Remmers
Location of central respiratory chemoreceptors in the developing tadpole
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R921 - R928.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. Peever, A. Necakov, and J. Duffin
Nucleus raphe obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices
J Appl Physiol, January 1, 2001; 90(1): 269 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. T. AYAS, R. BROWN, and S. A. SHEA
Hypercapnia Can Induce Arousal from Sleep in the Absence of Altered Respiratory Mechanoreception
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1004 - 1008.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
E. Nattie and A. Li
Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat
J Appl Physiol, July 1, 2000; 89(1): 153 - 162.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. C. Solomon, N. H. Edelman, and M. H. O'Neal III
CO2/H+ chemoreception in the cat pre-Botzinger complex in vivo
J Appl Physiol, June 1, 2000; 88(6): 1996 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Li, M. Randall, and E. E. Nattie
CO2 microdialysis in retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep
J Appl Physiol, September 1, 1999; 87(3): 910 - 919.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. E. Nattie, J. S. Erlichman, and A. Li
Brain stem lesion size determined by DEAD red or conjugation of neurotoxin to fluorescent beads
J Appl Physiol, December 1, 1998; 85(6): 2370 - 2375.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. V. Forster
Invited Editorial on "Ventilatory effects of glial dysfunction in a rat brain stem chemoreceptor region"
J Appl Physiol, November 1, 1998; 85(5): 1597 - 1598.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. Erlichman, A. Li, and E. E. Nattie
Ventilatory effects of glial dysfunction in a rat brain stem chemoreceptor region
J Appl Physiol, November 1, 1998; 85(5): 1599 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B G Lindsey, A Arata, K F Morris, Y M Hernandez, and R Shannon
Medullary raphe neurones and baroreceptor modulation of the respiratory motor pattern in the cat
J. Physiol., November 1, 1998; 512(3): 863 - 882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
L. Bellodi, G. Perna, D. Caldirola, C. Arancio, A. Bertani, and D. Di Bella
CO2-Induced Panic Attacks: A Twin Study
Am J Psychiatry, September 1, 1998; 155(9): 1184 - 1188.
[Abstract] [Full Text]

Home page
 J. Physiol.Home page
W. Wang, J. H Pizzonia, and G. B Richerson
Chemosensitivity of rat medullary raphe neurones in primary tissue culture
J. Physiol., September 1, 1998; 511(2): 433 - 450.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. V. Forster, L. G. Pan, T. F. Lowry, T. Feroah, W. M. Gershan, A. A. Whaley, M. M. Forster, and B. Sprtel
Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons
J Appl Physiol, January 1, 1998; 84(1): 129 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Li and E. E. Nattie
Focal central chemoreceptor sensitivity in the RTN studied with a CO2 diffusion pipette in vivo
J Appl Physiol, August 1, 1997; 83(2): 420 - 428.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Akilesh, M. Kamper, A. Li, and E. E. Nattie
Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats
J Appl Physiol, February 1, 1997; 82(2): 469 - 479.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online