Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 79: 1991-1997, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fagette, S.
Right arrow Articles by Gauquelin, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fagette, S.
Right arrow Articles by Gauquelin, G.

Journal of Applied Physiology, Vol 79, Issue 6 1991-1997, Copyright © 1995 by American Physiological Society

ARTICLES

Central and peripheral sympathetic activities in rats during recovery from simulated weightlessness

S. Fagette, L. Somody, F. Bouzeghrane, J. M. Cottet-Emard, C. Gharib and G. Gauquelin
Laboratoire de Physiologie de l'Environnement, Lyon, France.

Rats were tail suspended, keeping their forelimbs weight bearing for 14 days, and then allowed to recover for a short (6-h) or a long (24-h) period to assess the behavior of the sympathetic nervous system after weightless simulation. Sympathetic activity was determined by measuring norepinephrine (NE) turnover in the brain stem cell groups involved in central blood pressure control and in organs playing a key role in the cardiovascular regulation (heart and kidneys). The NE turnover was greatly reduced in the rostral (-56%; P < 0.001) and caudal (-73%; P < 0.001) A2 nucleus of suspended rats but was unchanged in the A1, A5, and A6 cell groups compared with attached rats. The NE turnover in the cardiac atria (-34%; P < 0.001) and ventricles (-35%; P < 0.001) and kidneys (-31%; P < 0.001) was decreased after suspension. The central and peripheral sympathetic activities returned to normal within 24 h of release from suspension, but there was hyperactivity after 6 h of recovery. This raises the problem of interpreting the results obtained in animals killed a few hours after return from spaceflight.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L.-F. Zhang, J.-H. Cheng, X. Liu, S. Wang, Y. Liu, H.-B. Lu, and J. Ma
Cardiovascular changes of conscious rats after simulated microgravity with and without daily -Gx gravitation
J Appl Physiol, October 1, 2008; 105(4): 1134 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Edgell, K. A. Zuj, D. K. Greaves, J. K. Shoemaker, M.-A. Custaud, P. Kerbeci, P. Arbeille, and R. L. Hughson
WISE-2005: adrenergic responses of women following 56-days, 6{degrees} head-down bed rest with or without exercise countermeasures
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2343 - R2352.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. K. Shoemaker, C. S. Hogeman, and L. I. Sinoway
Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R1084 - R1090.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Shoemaker, C. S. Hogeman, U. A. Leuenberger, M. D. Herr, K. Gray, D. H. Silber, and L. I. Sinoway
Sympathetic discharge and vascular resistance after bed rest
J Appl Physiol, February 1, 1998; 84(2): 612 - 617.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online