Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 79: 1206-1211, 1995;
8750-7587/95 $5.00
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Journal of Applied Physiology, Vol 79, Issue 4 1206-1211, Copyright © 1995 by American Physiological Society


ARTICLES

Effect of graded epinephrine infusion on blood lactate response to exercise

M. J. Turner, E. T. Howley, H. Tanaka, M. Ashraf, D. R. Bassett Jr and D. J. Keefer
University of Tennessee, Knoxville 37996-2700, USA.

In an attempt to determine whether the lactate threshold (LT) is the result of a sudden increase in plasma epinephrine (Epi), eight healthy college-aged males (22.4 +/- 0.4 yr) were recruited to perform three cycle ergometer exercise tests. Each subject performed a graded exercise test (GXT) to determine LT, Epi threshold, and norepinephrine threshold (64.6 +/- 2.4, 62.5 +/- 2.4, and 60.8 +/- 4.3% peak oxygen uptake, respectively). Each subject also completed, in random order, two 30-min submaximal (20% peak oxygen uptake below LT) exercise tests. During one test, graded Epi infusions were carried out at rates of 0.02-0.12 micrograms.kg-1.min-1; the other served as a control test. Infusion resulted in plasma Epi concentrations similar to those observed during GXT. The increase in blood lactate with Epi infusion was significantly greater than that during the control test (3.0 +/- 0.3 vs. 1.4 +/- 0.1 mmol/l at minute 30) but did not approach levels exhibited during GXT. We suggest an interaction of the increasing plasma Epi with other factors may be responsible for the sudden increase in blood lactate during graded exercise.


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