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Journal of Applied Physiology, Vol 79, Issue 3 986-1001, Copyright © 1995 by American Physiological Society
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R. W. Glenny, N. L. Polissar, S. McKinney and H. T. Robertson
Department of Medicine, University of Washington, Seattle 98191, USA.
This study investigates temporal changes in regional pulmonary perfusion. Five dogs were studied with five or six different radiolabeled microspheres being injected via a central vein over 30 s every 20 min. The lungs of each animal were cubed into 1.9 cm3 pieces with spatial coordinates noted for each piece. Within individual pieces, the coefficient of variation of regional perfusion over time was 17.2 +/- 6.8% (SD) and across dogs accounted for 7.26 +/- 5.7% of total perfusion heterogeneity. Temporal variability or "twinkling" was not random. When lung pieces with similar temporal flow patterns were grouped together (regardless of spatial location), groups were more tightly clustered in space than expected by chance. Statistical clustering methods revealed regulation of blood flow on a large scale (lobar arteries), and fractal analyses suggested regulation existed on a smaller scale (arterioles). We conclude that regional pulmonary perfusion is heterogeneous over time in a nonrandom pattern and that pieces clustered by temporal patterns of perfusion are neighbors in the spatial domain.
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M. Kleen, M. Welte, P. Lackermeier, O. Habler, G. Kemming, and K. Messmer Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis J Appl Physiol, December 1, 1997; 83(6): 1832 - 1841. [Abstract] [Full Text] [PDF]
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R. W. Glenny, S. McKinney, and H. T. Robertson Spatial pattern of pulmonary blood flow distribution is stable over days J Appl Physiol, March 1, 1997; 82(3): 902 - 907. [Abstract] [Full Text] [PDF]
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H. T. Robertson, R. W. Glenny, D. Stanford, L. M. McInnes, D. L. Luchtel, and D. Covert High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres J Appl Physiol, March 1, 1997; 82(3): 943 - 953. [Abstract] [Full Text] [PDF]
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