Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 79: 812-817, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martin, R. J.
Right arrow Articles by Haxhiu, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martin, R. J.
Right arrow Articles by Haxhiu, M. A.

Journal of Applied Physiology, Vol 79, Issue 3 812-817, Copyright © 1995 by American Physiological Society

ARTICLES

Neurochemical control of tissue resistance in piglets

R. J. Martin, I. A. Dreshaj, M. J. Miller and M. A. Haxhiu
Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA.

Lung resistance may be influenced by chemoreceptor activity and modulated by inspiratory neural output; however, it is unknown whether the contractile elements of lung tissue participate in these changes during early development. In anesthetized paralyzed open-chest piglets, we measured phrenic electroneurogram, lung resistance (RL), and tissue resistance utilizing alveolar capsules to partition the hypercapnic and hypoxic responses of RL into tissue (Rti) and airway resistance (Raw) components. Inhalation of 7% CO2 significantly increased RL (7.4 +/- 0.5 to 11.3 +/- 0.6 cmH2O.l-1.s), Rti (5.2 +/- 0.5 to 6.9 +/- 0.5 cmH2O.l-1.s), and Raw (2.2 +/- 0.2 to 4.4 +/- 0.4 cmH2O.l-1.s). Inhalation of 12% O2 caused more modest increases in RL, Rti, and Raw. Oscillations in tracheal and alveolar pressures appeared in synchrony with phrenic activity in response to both chemoreceptor stimuli. Cholinergic blockade eliminated these oscillations and significantly reduced the hypercapnic and hypoxic responses of RL, Rti, and Raw. These data demonstrate for the first time that hypercapnia and hypoxia elicit a cholinergically mediated increase in Rti which, just like the airway component of RL, is modulated by inspiratory neural output and is present during early development. Such coordination in neural function throughout the respiratory system may serve to optimize gas exchange during early postnatal life.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. A. Haxhiu, P. Kc, C. T. Moore, S. S. Acquah, C. G. Wilson, S. I. Zaidi, V. J. Massari, and D. G. Ferguson
Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses
J Appl Physiol, June 1, 2005; 98(6): 1961 - 1982.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Y. Khassawneh, I. A. Dreshaj, S. Liu, C.-H. Chang, M. A. Haxhiu, and R. J. Martin
Endogenous nitric oxide modulates responses of tissue and airway resistance to vagal stimulation in piglets
J Appl Physiol, August 1, 2002; 93(2): 450 - 456.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. C. Iben, I. A. Dreshaj, C. F. Farver, M. A. Haxhiu, and R. J. Martin
Role of endogenous nitric oxide in hyperoxia-induced airway hyperreactivity in maturing rats
J Appl Physiol, September 1, 2000; 89(3): 1205 - 1212.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online