Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol 79: 771-780, 1995;
8750-7587/95 $5.00
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Journal of Applied Physiology, Vol 79, Issue 3 771-780, Copyright © 1995 by American Physiological Society

ARTICLES

Analysis of low-frequency lung impedance in rabbits with nonlinear models

R. Peslin, C. Saunier, C. Duvivier and M. Marchand
Unite 14 de Physiopathologie Respiratoire, Institut National de la Sante et de la Recherche Medicale, Universite Henri Poincare Nancy I, Vandoeuvre-les-Nancy, France.

Lung mechanics was studied in six paralyzed tracheotomized rabbits ventilated with a specially devised computer-controlled ventilator. The target flow waveform contained noninteger multiple frequencies ranging from 0.83 to 6-10 Hz and met a neither-sum-nor-difference criterion to minimize the effects of nonlinearity (B. Suki and K. Lutchen. IEEE Trans. Biomed. Eng. 39: 1142-1151, 1992). The actual flow, however, contained harmonics of the two lowest frequencies. Measurements were performed at mean airway pressure (Paw) levels of 8 and 12 hPa and during histamine-induced bronchoconstriction. Smooth impedance curves were observed in unchallenged rabbits at low mean Paw levels. In contrast, unrealistic impedance fluctuations, suggestive of cross talk from the unwanted frequency components in the flow input, were seen at high mean Paw levels and during acute bronchoconstriction. Model analysis was performed by using the actual flow signal as an input to various nonlinear models. The impedance fluctuations observed at high mean Paw levels were well simulated by a model featuring a volume-dependent elastance, and those observed after histamine were almost perfectly reproduced by a model where resistance increased with the reciprocal of lung volume. We conclude that impedance data biased by cross talk may provide useful information on the presence and nature of respiratory system nonlinearities.


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