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J Appl Physiol 79: 675-686, 1995;
8750-7587/95 $5.00
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Journal of Applied Physiology, Vol 79, Issue 3 675-686, Copyright © 1995 by American Physiological Society

ARTICLES

Oxidants and antioxidants in exercise

C. K. Sen
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.

There is consistent evidence from human and animal studies that strenuous physical exercise may induce a state wherein the antioxidant defenses of several tissues are overwhelmed by excess reactive oxygen. A wide variety of physiological and dietary antioxidants act in concert to evade such a stress. Submaximal long-duration exercise training may augment the physiological antioxidant defenses in several tissues; however, this enhanced protection may not be sufficient to completely protect highly fit individuals from exhaustive exercise-induced oxidative stress. Regular physical activity in association with dietary habits that ensure adequate supply of a combination of appropriate antioxidants may be expected to yield desirable results. The significance of this area of research, current state of information, and possibilities of further investigation are briefly reviewed.


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