| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 79, Issue 2 623-631, Copyright © 1995 by American Physiological Society
ARTICLES |
C. M. Burge and S. L. Skinner
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
An improved protocol was applied to the use of carboxyhemoglobin (HbCO) saturation for the estimation of body hemoglobin (Hb) mass, red blood cell volume, and blood volume and was appraised in normal volunteers. A body size-related dose of CO (50-90 ml), estimated to change HbCO saturation by 6.5%, was introduced into a low-volume (2.8 liters) closed-circuit rebreathing system and allowed to equilibrate over 10 min. Plots of venous HbCO were characterized by a plateau after 8 min, which remained stable for at least 40 min. No loss of CO from the vascular space was evident. Three estimations of Hb mass at weekly intervals in seven subjects produced a coefficient of variation of 0.8% such that, in the absence of physiological influences, changes as little as 1.5% in Hb mass are detectable. Venesection [498 +/- 16 (SE) ml] in seven subjects was associated with a measured decrease in Hb mass after 1 wk equal to the calculated loss. Blood volume was, however, largely restored by plasma expansion. The method is sensitive and precise. It can be used safely and repeatedly in normal volunteers and hospital patients.
This article has been cited by other articles:
|
|
 |
|
  A. Eastwood, W. G. Hopkins, P. C. Bourdon, R. T. Withers, and C. J. Gore Stability of hemoglobin mass over 100 days in active men J Appl Physiol, April 1, 2008; 104(4): 982 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Boning Erythropoietin effect on red cell and plasma volume J. Physiol., January 1, 2008; 586(1): 303 - 303. [Full Text] [PDF]
|
|
|
|
|
|
D. Fischer, P. Arbeille, J. K. Shoemaker, D. D. O'Leary, and R. L. Hughson Altered hormonal regulation and blood flow distribution with cardiovascular deconditioning after short-duration head down bed rest J Appl Physiol, December 1, 2007; 103(6): 2018 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Neya, T. Enoki, Y. Kumai, T. Sugoh, and T. Kawahara The effects of nightly normobaric hypoxia and high intensity training under intermittent normobaric hypoxia on running economy and hemoglobin mass J Appl Physiol, September 1, 2007; 103(3): 828 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Wilson, M. Lopez, M. Vargas, C. Julian, W. Tellez, A. Rodriguez, A. Bigham, J. F. Armaza, S. Niermeyer, M. Shriver, et al. Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1313 - R1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vargas, E. Vargas, C. G. Julian, J. F. Armaza, A. Rodriguez, W. Tellez, S. Niermeyer, M. Wilson, E. Parra, M. Shriver, et al. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1303 - R1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lundby, J. J. Thomsen, R. Boushel, M. Koskolou, J. Warberg, J. A. L. Calbet, and P. Robach Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume J. Physiol., January 1, 2007; 578(1): 309 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Gore, F. A. Rodriguez, M. J. Truijens, N. E. Townsend, J. Stray-Gundersen, and B. D. Levine Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4,000-5,500 m) J Appl Physiol, November 1, 2006; 101(5): 1386 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Wehrlin, P. Zuest, J. Hallen, and B. Marti Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes J Appl Physiol, June 1, 2006; 100(6): 1938 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Bruce and E. N. Bruce Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multicompartment model J Appl Physiol, April 1, 2006; 100(4): 1171 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gonzalez-Alonso, S. P. Mortensen, E. A. Dawson, N. H. Secher, and R. Damsgaard Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin J. Physiol., April 1, 2006; 572(1): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J P Wehrlin, B Marti, and T Noakes Live high-train low associated with increased haemoglobin mass as preparation for the 2003 World Championships in two native European world class runners * Commentary Br. J. Sports Med., February 1, 2006; 40(2): e3 - e3. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Gore, W. G. Hopkins, and C. M. Burge Errors of measurement for blood volume parameters: a meta-analysis J Appl Physiol, November 1, 2005; 99(5): 1745 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Friedmann, F Frese, E Menold, F Kauper, J Jost, and P Bartsch Individual variation in the erythropoietic response to altitude training in elite junior swimmers Br. J. Sports Med., March 1, 2005; 39(3): 148 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Waters, S. H. Platts, B. M. Mitchell, P. A. Whitson, and J. V. Meck Plasma volume restoration with salt tablets and water after bed rest prevents orthostatic hypotension and changes in supine hemodynamic and endocrine variables Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H839 - H847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. U. Saunders, R. D. Telford, D. B. Pyne, R. B. Cunningham, C. J. Gore, A. G. Hahn, and J. A. Hawley Improved running economy in elite runners after 20 days of simulated moderate-altitude exposure J Appl Physiol, March 1, 2004; 96(3): 931 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Farstad, J. K. Heltne, S. E. Rynning, H. Onarheim, A. Mongstad, F. Eliassen, and P. Husby Can the use of methylprednisolone, vitamin C, or {alpha}-trinositol prevent cold-induced fluid extravasation during cardiopulmonary bypass in piglets? J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 525 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Bruce and M. C. Bruce A multicompartment model of carboxyhemoglobin and carboxymyoglobin responses to inhalation of carbon monoxide J Appl Physiol, September 1, 2003; 95(3): 1235 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Richardson, E. A. Noyszewski, B. Saltin, and J. Gonzalez-Alonso Effect of mild carboxy-hemoglobin on exercising skeletal muscle: intravascular and intracellular evidence Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1131 - R1139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. P. McMahon, K. Mason, S. L. Skinner, C. M. Burge, L. E. Grigg, and G. J. Becker Effects of haemoglobin normalization on quality of life and cardiovascular parameters in end-stage renal failure Nephrol. Dial. Transplant., September 1, 2000; 15(9): 1425 - 1430. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
