Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 79: 434-438, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gabrielsen, A.
Right arrow Articles by Henriksen, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gabrielsen, A.
Right arrow Articles by Henriksen, O.

Journal of Applied Physiology, Vol 79, Issue 2 434-438, Copyright © 1995 by American Physiological Society

ARTICLES

Effect of microgravity on forearm subcutaneous vascular resistance in humans

A. Gabrielsen, P. Norsk, R. Videbaek and O. Henriksen
Danish Aerospace Medical Centre of Research, Rigshospitalet 7522, Copenhagen, Denmark.

To test the hypothesis that the subcutaneous vascular constrictor response to an orthostatic stress in humans is augmented after exposure to microgravity, the following experiment was performed. Four male astronauts underwent a standardized stepwise lower body negative pressure (LBNP) profile 5 mo before and between 24 and 40 h after completion of the 10-day Spacelab D2 mission (STS-55). Forearm subcutaneous blood flow was continuously measured during LBNP by the 133Xe washout technique, and forearm subcutaneous vascular resistance (FSVR) was estimated by dividing mean arterial pressure by forearm subcutaneous blood flow. Relative to the pre-LBNP level, FSVR increased to 169 +/- 42 (P < 0.05), 176 +/- 12 (P < 0.05) and 158 +/- 27% during postflight LBNP of -11 (20 min), -23 (5 min), and -30 (7.5 min) mmHg, respectively. During the same LBNP levels of the same durations preflight, FSVR increased to 121 +/- 11 (not significant), 139 +/- 12 (P < 0.05), and 135 +/- 13% (P < 0.05), respectively. Thus, FSVR increased more promptly and, in three of the four subjects, was more pronounced during postflight than during preflight LBNP. In conclusion, the FSVR response was more prompt and tended to be accentuated after 1-2 days after exposure to 10 days of microgravity and could act as a defense mechanism to alleviate decreased orthostatic tolerance.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
D. E. Watenpaugh, D. D. O'Leary, S. M. Schneider, S. M. C. Lee, B. R. Macias, K. Tanaka, R. L. Hughson, and A. R. Hargens
Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance
J Appl Physiol, December 1, 2007; 103(6): 1964 - 1972.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Gabrielsen and P. Norsk
Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg
J Appl Physiol, September 1, 2007; 103(3): 959 - 962.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. E. Wilson, M. Shibasaki, J. Cui, B. D. Levine, and C. G. Crandall
Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans
J Appl Physiol, June 1, 2003; 94(6): 2113 - 2118.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L.-F. Zhang
Vascular adaptation to microgravity: what have we learned?
J Appl Physiol, December 1, 2001; 91(6): 2415 - 2430.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Shoemaker, C. S. Hogeman, U. A. Leuenberger, M. D. Herr, K. Gray, D. H. Silber, and L. I. Sinoway
Sympathetic discharge and vascular resistance after bed rest
J Appl Physiol, February 1, 1998; 84(2): 612 - 617.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online