Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol 79: 146-150, 1995;
8750-7587/95 $5.00
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Journal of Applied Physiology, Vol 79, Issue 1 146-150, Copyright © 1995 by American Physiological Society

ARTICLES

Effects of glutamine on the immune system: influence of muscular exercise and HIV infection

T. Rohde, H. Ullum, J. P. Rasmussen, J. H. Kristensen, E. Newsholme and B. K. Pedersen
Laboratory of Infectious Diseases, Copenhagen Muscle Research Centre, Rigshospitalet, Denmark.

Glutamine increased the proliferative response and the lymphokine-activated killer cell activity of blood mononuclear cells isolated from normal healthy subjects (n = 6) in a dose-dependent manner, with optimum at 0.3-1.0 mM. The relative fraction of CD3+, CD4+, CD8+, CD14+, CD16+, and CD19+ cells was not changed by glutamine at a concentration of 0.6 mM, except in the phytohemagglutinin-stimulated proliferation experiment where the fraction of CD4+, and therefore CD3+ cells, increased. The natural killer cell activity was not influenced by glutamine. Human immunodeficiency virus (HIV)-seropositive subjects (n = 8) who performed concentric bicycle exercise for 1 h at 75% of maximal O2 consumption had an overall lower phytohemagglutinin-stimulated proliferative response, compared with the HIV-seronegative control group (n = 7). The proliferation during exercise was lower in both the HIV-seropositive and the HIV-seronegative group. Addition of glutamine in vitro did not normalize the lower proliferation in the HIV-seropositive group or the attenuated proliferation seen during exercise in both groups.


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