Journal of Applied Physiology, Vol 78, Issue 6 2207-2211, Copyright © 1995 by American Physiological Society

ARTICLES

Energy expenditure during antiorthostatic bed rest (simulated microgravity)

R. J. Gretebeck, D. A. Schoeller, E. K. Gibson and H. W. Lane
Nutritional Biochemistry and Stable Isotope Laboratories, National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058, USA.

Few studies have addressed the interaction between energy balance and lean body mass in healthy subjects during spaceflight or its simulations. We used doubly labeled water to measure total energy expenditure (TEE) in nine healthy adult men during two 7-day periods, once before and once during a 10-day head-down bed-rest period. Mean TEE was 21% less during than before bed rest; however, neither basal (BEE) nor resting (REE) energy expenditures changed, implying that the lesser TEE resulted from a reduction in physical activity. During the bed-rest period, energy intake was 563 +/- 280 kcal/day higher than TEE (P < 0.05) but body weight, fluid balance, BEE, and REE did not change relative to before bed rest. However, the small but statistically significant increase in body fat (0.44 +/- 0.67 kg, P < 0.05) during the bed-rest period suggests that body weight alone does not accurately reflect changes in energy balance during antiorthostatic bed rest.

This article has been cited by other articles:

				A. Bergouignan, G. Trudel, C. Simon, A. Chopard, D. A. Schoeller, I. Momken, S. B. Votruba, M. Desage, G. C. Burdge, G. Gauquelin-Koch, et al. Physical Inactivity Differentially Alters Dietary Oleate and Palmitate Trafficking Diabetes, February 1, 2009; 58(2): 367 - 376. [Abstract] [Full Text] [PDF]

				G. Biolo, F. Agostini, B. Simunic, M. Sturma, L. Torelli, J. C. Preiser, G. Deby-Dupont, P. Magni, F. Strollo, P. di Prampero, et al. Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest Am. J. Clinical Nutrition, October 1, 2008; 88(4): 950 - 958. [Abstract] [Full Text] [PDF]

				R. C. Boston and P. J. Moate NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R395 - R403. [Abstract] [Full Text] [PDF]

				N. Brooks, G. J. Cloutier, S. M. Cadena, J. E. Layne, C. A. Nelsen, A. M. Freed, R. Roubenoff, and C. Castaneda-Sceppa Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit J Appl Physiol, July 1, 2008; 105(1): 241 - 248. [Abstract] [Full Text] [PDF]

				E. L. Schuck, M. Grant, and H. Derendorf Effect of Simulated Microgravity on the Disposition and Tissue Penetration of Ciprofloxacin in Healthy Volunteers J. Clin. Pharmacol., July 1, 2005; 45(7): 822 - 831. [Abstract] [Full Text] [PDF]

				T. P. Stein, M. R. Donaldson, M. J. Leskiw, M. D. Schluter, D. W. Baggett, and G. Boden Branched-chain amino acid supplementation during bed rest: effect on recovery J Appl Physiol, April 1, 2003; 94(4): 1345 - 1352. [Abstract] [Full Text] [PDF]

				S. Blanc, A. Geloen, S. Normand, C. Gharib, and L. Somody Simulated weightlessness alters the nycthemeral distribution of energy expenditure in rats J. Exp. Biol., January 12, 2001; 204(23): 4107 - 4113. [Abstract] [Full Text] [PDF]

				S. Blanc, S. Normand, C. Pachiaudi, J.-O. Fortrat, M. Laville, and C. Gharib Fuel Homeostasis during Physical Inactivity Induced by Bed Rest J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2223 - 2233. [Abstract] [Full Text]

				T. P. Stein and M. J. Leskiw Oxidant damage during and after spaceflight Am J Physiol Endocrinol Metab, March 1, 2000; 278(3): E375 - E382. [Abstract] [Full Text] [PDF]

				T. P. Stein, M. J. Leskiw, M. D. Schluter, M. R. Donaldson, and I. Larina Protein kinetics during and after long-duration spaceflight on MIR Am J Physiol Endocrinol Metab, June 1, 1999; 276(6): E1014 - E1021. [Abstract] [Full Text] [PDF]

				T. P. Stein, M. J. Leskiw, M. D. Schluter, R. W. Hoyt, H. W. Lane, R. E. Gretebeck, and A. D. LeBlanc Energy expenditure and balance during spaceflight on the space shuttle Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1739 - R1748. [Abstract] [Full Text] [PDF]

				S. Blanc, S. Normand, P. Ritz, C. Pachiaudi, L. Vico, C. Gharib, and G. Gauquelin-Koch Energy and Water Metabolism, Body Composition, and Hormonal Changes Induced by 42 Days of Enforced Inactivity and Simulated Weightlessness J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4289 - 4297. [Abstract] [Full Text]