Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 78: 2033-2038, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Proctor, D. N.
Right arrow Articles by Lemon, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Proctor, D. N.
Right arrow Articles by Lemon, P. W.

Journal of Applied Physiology, Vol 78, Issue 6 2033-2038, Copyright © 1995 by American Physiological Society

ARTICLES

Oxidative capacity of human muscle fiber types: effects of age and training status

D. N. Proctor, W. E. Sinning, J. M. Walro, G. C. Sieck and P. W. Lemon
Applied Physiology Research Laboratory, School of Exercise, Leisure, and Sport, Kent State University 44242, Ohio, USA.

Morphometry and oxidative capacity of slow-twitch (type I) and fast-twitch (type IIa and IIb) muscle fibers obtained from vastus lateralis needle biopsies were compared between younger (21-30 yr) and older (51-62 yr) normal fit (maximal O2 uptake = 47.0 vs. 32.3 ml.kg-1.min-1) and endurance-trained (66.3 vs. 52.7 ml.kg-1.min-1) men (n = 6/group). The older groups had smaller type IIa (31%) and IIb (40%) fiber areas and fewer capillaries surrounding these fibers than did younger groups. The reduced type II fiber areas and capillary contacts associated with aging were also observed in the older trained men. However, the capillary supply per unit type II fiber area was not affected by age but was enhanced by training. Additionally, on the basis of quantitative histochemical analysis, succinate dehydrogenase activities of type IIa fibers in the older trained men [4.07 +/- 0.68 (SD) mmol.min-1.l-1] were similar to those observed in younger trained men (4.00 +/- 0.48 mmol.min-1.l-1) and twofold higher than in older normal fit men (2.01 +/- 0.65 mmol.min-1.l-1; age x fitness interaction, P < 0.05). Type I muscle fibers were unaffected by age but were larger and had more capillary contacts and higher succinate dehydrogenase activities in the trained groups. The findings of this study suggest that aging results in a decrease in type II fiber size and oxidative capacity in healthy men and that this latter effect can be prevented by endurance training. Conclusions regarding the effects of age and training status on muscle capillarization depend largely on how these data are expressed.


This article has been cited by other articles:


Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
L. Cui, Y. Ju, L. Ding, M. Trejo-Morales, and I. M. Olfert
Arteriolar and Venular Capillary Distribution in Skeletal Muscles of Old Rats
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2008; 63(9): 928 - 935.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. N. Daussin, J. Zoll, E. Ponsot, S. P. Dufour, S. Doutreleau, E. Lonsdorfer, R. Ventura-Clapier, B. Mettauer, F. Piquard, B. Geny, et al.
Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle
J Appl Physiol, May 1, 2008; 104(5): 1436 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. A. Parker, S. L. Smithmyer, J. A. Pelberg, A. D. Mishkin, and D. N. Proctor
Sex-specific influence of aging on exercising leg blood flow
J Appl Physiol, March 1, 2008; 104(3): 655 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. Moro, S. Bajpeyi, and S. R. Smith
Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity
Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E203 - E213.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Tanaka and D. R. Seals
Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms
J. Physiol., January 1, 2008; 586(1): 55 - 63.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. P. Gavin, R. S. Ruster, J. A. Carrithers, K. A. Zwetsloot, R. M. Kraus, C. A. Evans, D. J. Knapp, J. L. Drew, J. S. McCartney, J. P. Garry, et al.
No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men
J. Physiol., November 15, 2007; 585(1): 231 - 239.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. J. Behnke, M. D. Delp, D. C. Poole, and T. I. Musch
Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenation
J Appl Physiol, November 1, 2007; 103(5): 1757 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Basu, C. Dalla Man, M. Campioni, A. Basu, K. S. Nair, M. D. Jensen, S. Khosla, G. Klee, G. Toffolo, C. Cobelli, et al.
Two Years of Treatment With Dehydroepiandrosterone Does Not Improve Insulin Secretion, Insulin Action, or Postprandial Glucose Turnover in Elderly Men or Women
Diabetes, March 1, 2007; 56(3): 753 - 766.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. T. Korhonen, A. Cristea, M. Alen, K. Hakkinen, S. Sipila, A. Mero, J. T. Viitasalo, L. Larsson, and H. Suominen
Aging, muscle fiber type, and contractile function in sprint-trained athletes
J Appl Physiol, September 1, 2006; 101(3): 906 - 917.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Basu, C. Dalla Man, M. Campioni, A. Basu, G. Klee, G. Toffolo, C. Cobelli, and R. A. Rizza
Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction.
Diabetes, July 1, 2006; 55(7): 2001 - 2014.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Lopez-Soriano, C. Chiellini, M. Maffei, P. A. Grimaldi, and J. M. Argiles
Roles of Skeletal Muscle and Peroxisome Proliferator-Activated Receptors in the Development and Treatment of Obesity
Endocr. Rev., May 1, 2006; 27(3): 318 - 329.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Basu, R. Singh, A. Basu, C.M. Johnson, and R. A. Rizza
Effect of Nutrient Ingestion on Total-Body and Splanchnic Cortisol Production in Humans
Diabetes, March 1, 2006; 55(3): 667 - 674.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. A. Ryan, K. A. Zwetsloot, L. M. Westerkamp, R. C. Hickner, W. E. Pofahl, and T. P. Gavin
Lower skeletal muscle capillarization and VEGF expression in aged vs. young men
J Appl Physiol, January 1, 2006; 100(1): 178 - 185.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. N. Croley, K. A. Zwetsloot, L. M. Westerkamp, N. A. Ryan, A. M. Pendergast, R. C. Hickner, W. E. Pofahl, and T. P. Gavin
Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women
J Appl Physiol, November 1, 2005; 99(5): 1872 - 1879.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. R. Short, J. L. Vittone, M. L. Bigelow, D. N. Proctor, J. M. Coenen-Schimke, P. Rys, and K. S. Nair
Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training
J Appl Physiol, July 1, 2005; 99(1): 95 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. B Rossiter, R. A Howlett, H. H Holcombe, P. L Entin, H. E Wagner, and P. D Wagner
Age is no barrier to muscle structural, biochemical and angiogenic adaptations to training up to 24 months in female rats
J. Physiol., June 15, 2005; 565(3): 993 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. Krustrup, Y. Hellsten, and J. Bangsbo
Intense interval training enhances human skeletal muscle oxygen uptake in the initial phase of dynamic exercise at high but not at low intensities
J. Physiol., August 15, 2004; 559(1): 335 - 345.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. DeLorey, J. M. Kowalchuk, and D. H. Paterson
Effect of age on O2 uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise
J Appl Physiol, July 1, 2004; 97(1): 165 - 172.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Charifi, F. Kadi, L. Feasson, F. Costes, A. Geyssant, and C. Denis
Enhancement of microvessel tortuosity in the vastus lateralis muscle of old men in response to endurance training
J. Physiol., January 15, 2004; 554(2): 559 - 569.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Basu, E. Breda, A. L. Oberg, C. C. Powell, C. Dalla Man, A. Basu, J. L. Vittone, G. G. Klee, P. Arora, M. D. Jensen, et al.
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance: Contribution of Alterations in Insulin Secretion, Action, and Clearance
Diabetes, July 1, 2003; 52(7): 1738 - 1748.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. N. Proctor, S. C. Newcomer, D. W. Koch, K. U. Le, D. A. MacLean, and U. A. Leuenberger
Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men
J Appl Physiol, May 1, 2003; 94(5): 1859 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
Y. Kano, S. Shimegi, H. Furukawa, H. Matsudo, and T. Mizuta
Effects of Aging on Capillary Number and Luminal Size in Rat Soleus and Plantaris Muscles
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2002; 57(12): B422 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Hunter, B. R. Newcomer, R. L. Weinsier, D. L. Karapondo, D. E. Larson-Meyer, D. R. Joanisse, and M. M. Bamman
Age is independently related to muscle metabolic capacity in premenopausal women
J Appl Physiol, July 1, 2002; 93(1): 70 - 76.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Levine, C. Gregory, T. Nguyen, J. Shrager, L. Kaiser, N. Rubinstein, and G. Dudley
Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD
J Appl Physiol, March 1, 2002; 92(3): 1205 - 1213.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. H. Goodpaster, J. He, S. Watkins, and D. E. Kelley
Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes
J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5755 - 5761.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Kent-Braun and A. V. Ng
Skeletal muscle oxidative capacity in young and older women and men
J Appl Physiol, September 1, 2000; 89(3): 1072 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. Dubouchaud, G. E. Butterfield, E. E. Wolfel, B. C. Bergman, and G. A. Brooks
Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle
Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E571 - E579.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. N. Proctor, P. H. Shen, N. M. Dietz, T. J. Eickhoff, L. A. Lawler, E. J. Ebersold, D. L. Loeffler, and M. J. Joyner
Reduced leg blood flow during dynamic exercise in older endurance-trained men
J Appl Physiol, July 1, 1998; 85(1): 68 - 75.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Maltais, J. Jobin, M. J. Sullivan, S. Bernard, F. Whittom, K. J. Killian, M. Desmeules, M. Belanger, and P. LeBlanc
Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD
J Appl Physiol, May 1, 1998; 84(5): 1573 - 1580.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Sial, A. R. Coggan, R. C. Hickner, and S. Klein
Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects
Am J Physiol Endocrinol Metab, May 1, 1998; 274(5): E785 - E790.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. FLOREZ-DUQUET and R. B. McDONALD
Cold-Induced Thermoregulation and Biological Aging
Physiol Rev, April 1, 1998; 78(2): 339 - 358.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. N. Proctor and M. J. Joyner
Skeletal muscle mass and the reduction of VO2 max in trained older subjects
J Appl Physiol, May 1, 1997; 82(5): 1411 - 1415.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online