Journal of Applied Physiology AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 78: 1531-1536, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rossaint, R.
Right arrow Articles by Radermacher, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rossaint, R.
Right arrow Articles by Radermacher, P.

Journal of Applied Physiology, Vol 78, Issue 4 1531-1536, Copyright © 1995 by American Physiological Society

ARTICLES

Influence of mixed venous PO2 and inspired O2 fraction on intrapulmonary shunt in patients with severe ARDS

R. Rossaint, S. M. Hahn, D. Pappert, K. J. Falke and P. Radermacher
Klinik fur Anaesthesiologie und operative Intensivmedizin, Universitatsklinikum Rudolf Virchow, Freie Universitat, Berlin, Germany.

In 12 patients undergoing extracorporeal membrane oxygenation for treatment of severe acute respiratory distress syndrome (ARDS), we examined the effects of independent variations in mixed venous oxygen tension (PvO2) and inspired oxygen fraction (FIO2) on the distribution of ventilation and perfusion as assessed by the multiple inert gas elimination technique. Reducing the oxygen concentration of the constant gas stream through the membrane lungs allowed us to decrease the PvO2 by approximately 20 Torr independently of variations in cardiac output and FIO2 as well as to augment FIO2 without influencing PvO2. The interventions did not induce any change in heart rate or systemic or pulmonary hemodynamics. In general, neither during mechanical ventilation at FIO2 of 0.6 nor during mechanical ventilation at FIO2 of 1.0 did the reduced PvO2 cause variations in the distribution of pulmonary blood flow in our patients with severe ARDS. Nevertheless, in individual patients, decreasing PvO2 or ventilation at FIO2 of 1.0 was associated with changes in intrapulmonary shunt. Therefore, we conclude that it is not possible to predict the influence of such interventions in pulmonary gas exchange in the individual patient suffering from ARDS. Differences in the regulation of the local distribution of blood flow caused by the disease itself might explain this phenomenon.


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
R. A. McCahon, M. O. Columb, R. P. Mahajan, and J. G. Hardman
Validation and application of a high-fidelity, computational model of acute respiratory distress syndrome to the examination of the indices of oxygenation at constant lung-state
Br. J. Anaesth., September 1, 2008; 101(3): 358 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. Henzler, N. Hochhausen, R. Dembinski, S. Orfao, R. Rossaint, and R. Kuhlen
Parameters Derived from the Pulmonary Pressure Volume Curve, but Not the Pressure Time Curve, Indicate Recruitment in Experimental Lung Injury
Anesth. Analg., October 1, 2007; 105(4): 1072 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
M. Nirmalan, T. Willard, M. O. Columb, and P. Nightingale
Effect of changes in arterial-mixed venous oxygen content difference (C(a-{v})O2) on indices of pulmonary oxygen transfer in a model ARDS lung{{dagger}},{{dagger}}{{dagger}}
Br. J. Anaesth., April 1, 2001; 86(4): 477 - 485.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online