Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 78: 968-975, 1995;
8750-7587/95 $5.00
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Journal of Applied Physiology, Vol 78, Issue 3 968-975, Copyright © 1995 by American Physiological Society

ARTICLES

The effects of rM-CSF and rIL-6 therapy on immunosuppressed antiorthostatically suspended mice

J. W. Armstrong, K. Kirby-Dobbels and S. K. Chapes
Division of Biology, Kansas State University, Manhattan 66506, USA.

Antiorthostatically suspended mice had suppressed macrophage development in both unloaded and loaded bones, indicating a systemic effect. Bone marrow cells from those mice secreted less macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) than did control mice. Because M-CSF and IL-6 are important to bone marrow macrophage maturation, we formulated the hypothesis that suppressed macrophage development occurred as a result of the depressed levels of either M-CSF or IL-6. To test the hypothesis, mice were administered recombinant M-CSF or IL-6 intraperitoneally. We showed that recombinant M-CSF therapy, but not recombinant IL-6 therapy, reversed the suppressive effects of antiorthostatic suspension on macrophage development. These data suggest that bone marrow cells that produce M-CSF are affected by antiorthostatic suspension and may contribute to the inhibited maturation of bone marrow macrophage progenitors.


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