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J Appl Physiol 78: 810-813, 1995;
8750-7587/95 $5.00
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Journal of Applied Physiology, Vol 78, Issue 3 810-813, Copyright © 1995 by American Physiological Society

ARTICLES

Influence of spaceflight on the production of interleukin-3 and interleukin-6 by rat spleen and thymus cells

E. S. Miller, D. A. Koebel and G. Sonnenfeld
Medical Immunotherapy Laboratory, Don and Sybil Harrington Cancer Center, Amarillo, Texas 79106, USA.

Six adult male Sprague-Dawley rats were flown on the 7-day US space shuttle mission STS-54. After flight, the spleen and thymus from each animal were assayed for the capacity to secrete the cytokines interleukin-3 (IL-3) and IL-6. Spleen and thymus cells (5 x 10(6)/ml) were incubated for 48 h in the presence of 5 micrograms/ml of concanavalin A or 2 micrograms/ml of bacterial lipopolysaccharide to stimulate the production of IL-3 and IL-6. IL-3 activity was measured using the IL-3/colony-stimulating-factor-dependent cell line 32D. IL-6 activity was measured using the IL-6-dependent cell line 7TD1. Spleen and thymus cells harvested from flown rats secreted significantly higher titers of biologically active IL-3 compared with ground control rats. Spaceflight significantly enhanced IL-6 production by thymus, but not spleen, cells. The results of this study demonstrate that spaceflight can enhance the production of certain cytokines by cells of the immune system.


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