Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 78: 810-813, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miller, E. S.
Right arrow Articles by Sonnenfeld, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miller, E. S.
Right arrow Articles by Sonnenfeld, G.

Journal of Applied Physiology, Vol 78, Issue 3 810-813, Copyright © 1995 by American Physiological Society

ARTICLES

Influence of spaceflight on the production of interleukin-3 and interleukin-6 by rat spleen and thymus cells

E. S. Miller, D. A. Koebel and G. Sonnenfeld
Medical Immunotherapy Laboratory, Don and Sybil Harrington Cancer Center, Amarillo, Texas 79106, USA.

Six adult male Sprague-Dawley rats were flown on the 7-day US space shuttle mission STS-54. After flight, the spleen and thymus from each animal were assayed for the capacity to secrete the cytokines interleukin-3 (IL-3) and IL-6. Spleen and thymus cells (5 x 10(6)/ml) were incubated for 48 h in the presence of 5 micrograms/ml of concanavalin A or 2 micrograms/ml of bacterial lipopolysaccharide to stimulate the production of IL-3 and IL-6. IL-3 activity was measured using the IL-3/colony-stimulating-factor-dependent cell line 32D. IL-6 activity was measured using the IL-6-dependent cell line 7TD1. Spleen and thymus cells harvested from flown rats secreted significantly higher titers of biologically active IL-3 compared with ground control rats. Spaceflight significantly enhanced IL-6 production by thymus, but not spleen, cells. The results of this study demonstrate that spaceflight can enhance the production of certain cytokines by cells of the immune system.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. J. Pecaut, G. M. Miller, G. A. Nelson, and D. S. Gridley
Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses
J Appl Physiol, July 1, 2004; 97(1): 29 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Pecaut, G. A. Nelson, L. L. Peters, P. J. Kostenuik, T. A. Bateman, S. Morony, L. S. Stodieck, D. L. Lacey, S. J. Simske, and D. S. Gridley
Genetic Models in Applied Physiology: Selected Contribution: Effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions
J Appl Physiol, May 1, 2003; 94(5): 2085 - 2094.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Pecaut, S. J. Simske, and M. Fleshner
Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2072 - R2078.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. K. Chapes, S. J. Simske, G. Sonnenfeld, E. S. Miller, and R. J. Zimmerman
Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses
J Appl Physiol, June 1, 1999; 86(6): 2065 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Sonnenfeld, M. Foster, D. Morton, F. Bailliard, N. A. Fowler, A. M. Hakenewerth, R. Bates, and E. S. Miller Jr.
Spaceflight and development of immune responses
J Appl Physiol, October 1, 1998; 85(4): 1429 - 1433.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online