Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 78: 1065-1069, 1995;
8750-7587/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lapier, T. K.
Right arrow Articles by Cerny, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lapier, T. K.
Right arrow Articles by Cerny, F.

Journal of Applied Physiology, Vol 78, Issue 3 1065-1069, Copyright © 1995 by American Physiological Society

ARTICLES

Alterations in intramuscular connective tissue after limb casting affect contraction-induced muscle injury

T. K. Lapier, H. W. Burton, R. Almon and F. Cerny
Department of Physical Therapy and Exercise Science, State University of New York at Buffalo 14214, USA.

This study examined the effect of alterations in rat intramuscular connective tissue (CT), secondary to limb immobilization, on the muscle's susceptibility to contraction-induced injury. Hindlimbs were casted for 3 wk with the extensor digitorum longus muscle fixed in a shortened (IM-SP) or lengthened position (IM-LP). An age-matched control group remained uncasted. Extensor digitorum longus muscles were injured in vivo by using a motorized foot pedal that repeatedly flexed and extended the foot while the muscle was electrically stimulated during plantar flexion. Four hours postinjury, maximum isometric tetanic force (Po) was measured in vitro and was used as a functional index of muscle injury. Muscles were fixed, sectioned, and stained for later analysis. Intramuscular CT concentration, expressed as the ratio of CT area to muscle fiber area, was significantly higher in both IM-SP (0.153 +/- 0.003) and IM-LP (0.174 +/- 0.003) groups compared with controls (0.104 +/- 0.003). Po values of injured muscles both IM-LP and IM-SP were higher than the injured controls' Po of 9.41 +/- 0.63 N/cm2 (P < 0.05). Injured IM-LP muscle forces were significantly higher than those of IM-SP. This study demonstrated that limb immobilization increases intramuscular CT concentration, which is accompanied by attenuation of muscle injury. We conclude that remodeling of intramuscular CT affects the muscle's resistance to contraction-induced injury.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. L. Mackey, A. E. Donnelly, T. Turpeenniemi-Hujanen, and H. P. Roper
Skeletal muscle collagen content in humans after high-force eccentric contractions
J Appl Physiol, July 1, 2004; 97(1): 197 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. M. Lapointe, P. Fremont, and C. H. Cote
Adaptation to lengthening contractions is independent of voluntary muscle recruitment but relies on inflammation
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R323 - R329.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Kannus, L. Jozsa, T. L. N. Jarvinen, M. Kvist, T. Vieno, T. A. H. Jarvinen, A. Natri, and M. Jarvinen
Free mobilization and low- to high-intensity exercise in immobilization-induced muscle atrophy
J Appl Physiol, April 1, 1998; 84(4): 1418 - 1424.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online