| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 78, Issue 2 629-637, Copyright © 1995 by American Physiological Society
ARTICLES |
P. N. Dekhuijzen, G. Gayan-Ramirez, A. Bisschop, V. De Bock, R. Dom and M. Decramer
Respiratory Muscle Research Unit, University Hospital, Katholieke Universiteit Leuven, Belgium.
Triamcinolone (TR) causes type IIb fiber atrophy in the rat diaphragm, which is associated with changes in contractile properties. We investigated whether this is a direct effect of TR or the result of an accompanying loss of body and diaphragm weights. For 6 wk, adult rats received saline intramuscularly, TR (0.5 mg/kg im), or nutritional depletion (ND) that resulted in a similar (approximately 40%) reduction in body weight as TR. In these animals, the half-relaxation time of the diaphragm bundles increased, the force-frequency relationship shifted leftward, and the resistance to fatigue was increased. No histological changes were found in the ND diaphragm, in contrast to severe myogenic alterations in the TR diaphragm. Type IIb fiber cross-sectional area (CSA) in the TR diaphragm was reduced by 51%, whereas type I and IIa CSAs were unaffected. In the ND animals, the CSAs of type I, IIa, and IIb fibers were reduced by 31, 33, and 52%, respectively. Similar changes occurred in the deep part of the m. gastrocnemius. In conclusion, myogenic changes and selective type IIb fiber atrophy were caused by TR, whereas ND induced generalized fiber type atrophy without histological changes.
This article has been cited by other articles:
|
|
 |
|
  O Schakman, H Gilson, and J P Thissen Mechanisms of glucocorticoid-induced myopathy J. Endocrinol., April 1, 2008; 197(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Gilson, O. Schakman, L. Combaret, P. Lause, L. Grobet, D. Attaix, J. M. Ketelslegers, and J. P. Thissen Myostatin Gene Deletion Prevents Glucocorticoid-Induced Muscle Atrophy Endocrinology, January 1, 2007; 148(1): 452 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Schakman, H. Gilson, V. de Coninck, P. Lause, J. Verniers, X. Havaux, J. M. Ketelslegers, and J. P. Thissen Insulin-Like Growth Factor-I Gene Transfer by Electroporation Prevents Skeletal Muscle Atrophy in Glucocorticoid-Treated Rats Endocrinology, April 1, 2005; 146(4): 1789 - 1797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Verheul, C. B. Mantilla, W.-Z. Zhan, M. Bernal, P. N. R. Dekhuijzen, and G. C. Sieck Influence of corticosteroids on myonuclear domain size in the rat diaphragm muscle J Appl Physiol, November 1, 2004; 97(5): 1715 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Polla, G D'Antona, R Bottinelli, and C Reggiani Respiratory muscle fibres: specialisation and plasticity Thorax, September 1, 2004; 59(9): 808 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Lewis, H. Li, Z.-S. Huang, M. S. Biring, B. Cercek, and M. Fournier Influence of varying degrees of malnutrition on IGF-I expression in the rat diaphragm J Appl Physiol, August 1, 2003; 95(2): 555 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Z. Racz, G. Gayan-Ramirez, D. Testelmans, P. Cadot, K. De Paepe, E. Zador, F. Wuytack, and M. Decramer Early Changes in Rat Diaphragm Biology with Mechanical Ventilation Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 297 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fournier, Z.-S. Huang, H. Li, X. Da, B. Cercek, and M. I. Lewis Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R34 - R43. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Eason, S. L Dodd, and S. K Powers Use of Anabolic Steroids to Attenuate the Effects Glucocorticoids on the Rat Diaphragm Physical Therapy, January 1, 2003; 83(1): 29 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R Gosker, M. P. Engelen, H. van Mameren, P. J van Dijk, G. J van der Vusse, E. F. Wouters, and A. M. Schols Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease Am. J. Clinical Nutrition, July 1, 2002; 76(1): 113 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M Eason, S. L Dodd, S. K Powers, and A D. Martin Detrimental Effects of Short-term Glucocorticoid Use on the Rat Diaphragm Physical Therapy, February 1, 2000; 80(2): 160 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease . A Statement of the American Thoracic Society and European Respiratory Society Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): S2 - 40. [Full Text] [PDF]
|
|
|
|
|
|
G. Fruhbeck, A. C. Villaro, I. Monreal, and S. Santidrian Hormone-related, muscle-specific changes in protein metabolism and fiber type profile after faba bean intake J Appl Physiol, March 1, 1999; 86(3): 852 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. H. Van Balkom, W.-Z. Zhan, Y. S. Prakash, P. N. R. Dekhuijzen, and G. C. Sieck Corticosteroid effects on isotonic contractile properties of rat diaphragm muscle J Appl Physiol, October 1, 1997; 83(4): 1062 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Prezant, M. L. Karwa, B. Richner, D. Maggiore, E. I. Gentry, and J. Cahill Gender-specific effects of dexamethasone treatment on rat diaphragm structure and function J Appl Physiol, January 1, 1997; 82(1): 125 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Lewis, G. D. Horvitz, D. R. Clemmons, and M. Fournier Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E483 - E490. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
