| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 77, Issue 3 1474-1479, Copyright © 1994 by American Physiological Society
ARTICLES |
S. D. Caruthers and T. R. Harris
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235.
The spatial heterogeneity of pulmonary blood flow can be described by the relative dispersion (RD) of weight-flow histograms (RD = SD/mean). Glenny and Robertson (J. Appl. Physiol. 69: 532-545, 1990) showed that RD of flow in the lung is fractal in nature, characterized by the fractal dimension (D) and RD for the smallest realizable volume element (RDref). We studied the effects of increasing total pulmonary blood flow on D and RDref. In eight in situ perfused sheep lung preparations, 15-microns radio-labeled microspheres were injected into the pulmonary artery at five different blood flows ranging, in random order, from 1.5 to 5.0 l/m. The lungs were in zone 2 at the lower flows and in zone 3 at the higher flows. The lungs were removed, dried, cut into 2 x 2 x 2-cm3 pieces, weighed, and then counted for microsphere radioactivity. Fractal plots of log(weight) vs. log(RD) were constructed by iteratively combining neighboring pieces and then calculating RD with the increasingly larger portion size. D, which is one minus the slope of the fit through this plot, was 1.14 +/- 0.09 and did not change as blood flow increased. However, RDref decreased significantly (P < 0.01) as total flow increased. We conclude that the fractal nature of pulmonary blood flow distribution is not altered by changes in overall flow.
This article has been cited by other articles:
|
|
 |
|
  D. L. Levin, R. B. Buxton, J. P. Spiess, T. Arai, J. Balouch, and S. R. Hopkins Effects of age on pulmonary perfusion heterogeneity measured by magnetic resonance imaging J Appl Physiol, May 1, 2007; 102(5): 2064 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Robertson and M. P. Hlastala Microsphere maps of regional blood flow and regional ventilation J Appl Physiol, March 1, 2007; 102(3): 1265 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Kreck, M. A. Krueger, W. A. Altemeier, S. E. Sinclair, H. T. Robertson, E. D. Shade, J. Hildebrandt, W. J. E. Lamm, D. A. Frazer, N. L. Polissar, et al. Determination of regional ventilation and perfusion in the lung using xenon and computed tomography J Appl Physiol, October 1, 2001; 91(4): 1741 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Karau, R. H. Johnson, R. C. Molthen, A. H. Dhyani, S. T. Haworth, C. C. Hanger, D. L. Roerig, and C. A. Dawson Microfocal X-ray CT imaging and pulmonary arterial distensibility in excised rat lungs Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1447 - H1457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, S. L. Bernard, and H. T. Robertson Pulmonary blood flow remains fractal down to the level of gas exchange J Appl Physiol, August 1, 2000; 89(2): 742 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Sinclair, S. McKinney, R. W. Glenny, S. L. Bernard, and M. P. Hlastala Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse J Appl Physiol, June 1, 2000; 88(6): 2269 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Venegas and G. G. Galletti Low-pass filtering, a new method of fractal analysis: application to PET images of pulmonary blood flow J Appl Physiol, April 1, 2000; 88(4): 1365 - 1373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker, M. N. Gillespie, A. E. Taylor, and S. L. Martin Capillary filtration coefficient, vascular resistance, and compliance in isolated mouse lungs J Appl Physiol, October 1, 1999; 87(4): 1421 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Erickson, S. L. Bernard, R. W. Glenny, M. R. Fedde, N. L. Polissar, R. J. Basaraba, S. M. Walther, E. M. Gaughan, R. McMurphy, and M. P. Hlastala Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses J Appl Physiol, June 1, 1999; 86(6): 2034 - 2043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, S. Bernard, H. T. Robertson, and M. P. Hlastala Gravity is an important but secondary determinant of regional pulmonary blood flow in upright primates J Appl Physiol, February 1, 1999; 86(2): 623 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kleen, O. Habler, J. Hutter, G. Kemming, A. Podtschaske, M. Tiede, M. Welte, P. E. Keipert, S. Batra, N. S. Faithfull, et al. Hemodilution and hyperoxia locally change distribution of regional pulmonary perfusion in dogs Am J Physiol Heart Circ Physiol, February 1, 1998; 274(2): H520 - H528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kleen, B. Zwissler, and K. Messmer PEEP only partly restores disturbed distribution of regional pulmonary blood flow in lung injury Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H209 - H216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Parker, C. B. Cave, J. L. Ardell, C. R. Hamm, and S. G. Williams Vascular tree structure affects lung blood flow heterogeneity simulated in three dimensions J Appl Physiol, October 1, 1997; 83(4): 1370 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Glenny, S. McKinney, and H. T. Robertson Spatial pattern of pulmonary blood flow distribution is stable over days J Appl Physiol, March 1, 1997; 82(3): 902 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Robertson, R. W. Glenny, D. Stanford, L. M. McInnes, D. L. Luchtel, and D. Covert High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres J Appl Physiol, March 1, 1997; 82(3): 943 - 953. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
